Peripheral Artery Disease Clinical Trial
Official title:
A Randomized, Open-Label, Parallel, Multi-Center, Phase IV Study to Assess the Effect of Ticagrelor vs Clopidogrel on Adenosine-Induced Myocardial Blood Flow in Peripheral Artery Disease (PAD)Patients
The purpose of the study is to assess the effect of blood flow to the heart when subjects are treated with ticagrelor (Brilinta) or clopidogrel (antiplatelet drugs that stop the blood from clumping together) in patients with Peripheral Artery Disease (PAD).
The effects of ticagrelor and clopidogrel on adenosine-induced myocardial blood flow (MBF)
will be evaluated by cardiac 13N- ammonia positron emission tomography (PET) at rest
(baseline), acute dosing on Day 1, and at short term dosing on Day 7.
Subjects receiving ticagrelor will have additional pharmacokinetic (PK) blood samples
collected at specific time points to measure ticagrelor concentration in the blood.
Subjects' participation will be approximatetly 6 weeks.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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