Periodontitis Clinical Trial
— aPDTOfficial title:
Effect of the Photodynamic Therapy Mediated by Methylene Blue in Surfactant Medium as an Adjuvant in the Treatment of Parts With Apical Periodontitis and the Presence of Fistula: A Randomized, Controlled Double-blind Clinical Trial
NCT number | NCT06413836 |
Other study ID # | UCUUNINOVE |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | May 1, 2024 |
Est. completion date | January 2026 |
The goal of this clinical trial is to learn if adjuvant antimicrobial photodynamic therapy (aPDT) can help in the treatment in patients with pieces with apical periodontitis and the presence of fistula, in terms of reducing symptoms, resolution of fistula and the clinical signs of inflammation at the oral mucose, as well as, evaluation radiographic parameters. Participants will undergo conventional endodontic treatment at Group I (n=15) and will undergo conventional endodontic treatment combined with antimicrobial photodynamic therapy at Group II(n=15).
Status | Recruiting |
Enrollment | 30 |
Est. completion date | January 2026 |
Est. primary completion date | June 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: Patients must have a single-rooted tooth with apical periodontitis and the presence of fistula. Patients must be over 18 years of age. Exclusion Criteria: Patients with comorbidities such as cancer, diabetes, coagulation diseases, and anemia; Patients undergoing orthodontic treatment; Patients with periodontal pockets deeper than 4 mm; Patients taking antibiotics; Pregnant or lactating patients; Patients with parts that present the impossibility of performing absolute isolation. |
Country | Name | City | State |
---|---|---|---|
Uruguay | UCU | Montevideo |
Lead Sponsor | Collaborator |
---|---|
University of Nove de Julho |
Uruguay,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fistula presence | Clinical observation to check presence or absence of fistula | Day 15 | |
Secondary | Radiographic register | Radiolucent radiograph analysis defining improvement or absence of improvement of the bone lesion. | Day 0 and Day 30 |
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