GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis

Periodontitis Clinical Trial

Official title:

Usak University Faculty of Dentistry

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04689438
• Other study ID #: UsakU7
• Status: Completed
• Start date: October 8, 2020
• Est. completion date: December 28, 2020

Study information

• Verified date: November 2022
• Source: Usak University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response. Gingivitis is a disease characterized by inflammation of the gingiva that occurs in one or more areas without loss of attachments.1 in periodontitis, an inflammatory event that begins in the gingiva along with gingivitis spreads to the periodontal ligament, alveolar bone and soft tissues that support the tooth, causing the destruction of these structures.2 Cytokines are low molecular weight proteins that participate in the initial and active stages of inflammation and immunity. In periodontal disease pathogenesis, cytokine response has been reported to play a very critical role in determining disease progression.3 IL-1beta and IL-6 are key cytokines in chronic inflammatory diseases and have the potential to initiate bone loss and tissue destruction seen in periodontal disease.4the purpose of this study; it is to determine the degree of inflammation and periodontal destruction by determining the levels of IL-1beta and IL-6 cytokines in the gingival crevicular fluid of periodontal healthy and diseased individuals.

Description:

Periodontal measurement were done at 6 sites per tooth After clinical evaluation, individuals were divided into 3 groups

1. Healthy control groups:

clinically healthy gingiva

2. Gingivitis groups:

BOP score of 10% or greater and PD≤3mm

3. Periodontitis groups:

AL ≥5 mm, PD≥6 mm and tooth loss due to periodontitis of ≤4. GCF samples were collected using strips.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Est. completion date: December 28, 2020
• Est. primary completion date: December 25, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• have periodontitis

• have 16 permanent teeth

Exclusion Criteria:

• Systemic disease

• using drugs

Related Conditions & MeSH terms

• Gingivitis
• Periodontitis

Intervention

Diagnostic Test:
• gingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.

Locations

Country	Name	City	State
Turkey	University of Usak	Usak

Sponsors (1)

Lead Sponsor	Collaborator
Usak University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of IL-1Beta level	GCF was taken interproximal region.	GCF was taken within 1 week after clinical examination
Primary	Measurement of IL-6 level in GCF	GCF was taken interproximal region.	GCF was taken within 1 week after clinical examination