Periodontitis Clinical Trial
Official title:
Effects of Application Injectable Platelet-Rich Fibrin (i-PRF) as Adjunct Therapy in the Initial Treatment of Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of chronic periodontitis (SRP) and SRP in conjunction with injectable platelet-rich fibrin (i-PRF) application.
Current treatments of periodontitis have limited efficacy since they fail to suppress
microorganisms satisfactorily over time. The aim of present study was to investigate whether
there are differences between initial treatment of chronic periodontitis (SRP) and SRP in
conjunction with injectable platelet-rich fibrin (i-PRF) application.
Thirty patients with chronic periodontitis who had at least two sites with perriodontal
pocket depth (PPD) ≥ 4 mm on contralateral side will be involved in the study. Using a
split-mouth design, patients will be treated with SRP + I-PRF -(test group) or SRP
only-(control group). Gingival crevicular fluid (GCF) and subgingival plaque will be
collected with paper points (DentsplyMaillefer, Tulsa, Oklahoma, USA) at baseline and 1, 3
and 6 months after the treatment. The presence and concentrations of Aggregatibacter
actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi) and
Tannerella forsythia(Tf) will be analyzed by real-time polymerase chain reaction (qPCR).
Periodontal parameters, including bleeding on probing (BOP), probing pocket depth (PPD) and
the clinical attachment level (CAL), will be recorded on both sides, as well as concentration
of TNF-alpha (tumor necrosis factor alpha), ALP(alkaline phosphatase) and MMP-8
(matrix-metalloproteinase-8).
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