Periodontitis Clinical Trial
Official title:
T-PRF Contributes to Periodontal Healing
Verified date | January 2017 |
Source | Ataturk University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It was aimed to evaluate the contributions of T-PRF treatment combined with open flap debridement on biological markers in GCF and periodontal outcomes in chronic periodontitis patients. 29 patients (58 sites) with chronic periodontitis were treated either with autologous T-PRF with OFD or OFD alone. GCF growth factor levels and relative RANKL/OPG ratio at baseline and 2, 4 and 6 weeks postoperatively were analyzed, and clinical parameters such as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at baseline and 9 months after surgery were compromised.
Status | Completed |
Enrollment | 33 |
Est. completion date | November 2016 |
Est. primary completion date | June 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Patients with CP who had pocket depth = 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after initial treatment Exclusion Criteria: - The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Ataturk University |
Pradeep AR, Shetty SK, Garg G, Pai S. Clinical effectiveness of autologous platelet-rich plasma and Peptide-enhanced bone graft in the treatment of intrabony defects. J Periodontol. 2009 Jan;80(1):62-71. doi: 10.1902/jop.2009.080214 . — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Level of Growth Factor | Change from baseline growth factors levels of GCF at 6 weeks were measured by periopaper | 6 weeks | |
Secondary | relative RANKL/OPG ratio in GCF | Change in relative RANKL/OPG ratio from baseline to 6 weeks were measured by periopaper | 6 weeks | |
Secondary | Alteration of Clinical Attachment Level | Change from baseline Clinical Attachment Levels at 9 months were measured with periodontal probe. | 9 months | |
Secondary | Alteration of Periodontal Pocket Depth | Change from baseline Pocket Depth at 9 months were measured with periodontal probe. | 9 months | |
Secondary | Gingival Margin Level | Change from baseline to 9 months were measured with periodontal probe. | 9 months |
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