Periodontitis Clinical Trial
Official title:
Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial
The accumulation and maturation of oral biofilm in the gingival margin is widely recognised
to be the primary aetiological factor in the development of chronic gingivitis. Based on
this association, the current treatment of gingivitis is focused on biofilm disruption,
which will normally include mechanical processes, both professionally and at home. However,
for patients, it is not easy to achieve a proper level of plaque control. The efficient
plaque control techniques are very time consuming and require a special motivation and
skills for their optimum use. It was at this point where mouthwashes become important, due
to the fact that they include diverse types of antimicrobial agents to complement the
results of mechanical oral hygiene measures.
The essential oils have been presented as a realiable alternative to the "gold Standard"
(Chlorhexidine). However, it use has been limited clinically due to their alcohol contain.
Some years ago, a new alternative without alcohol has been launched to the market. This
formulation has not been already deeply tested specific antiplaque studies in which the
structure of the biofilm remained intact.
The aim of this study was to evaluate the in situ antiplaque effect of 2 antimicrobial
agents (based on an essential oils formulation with and without alcohol) in the short term
with a posterior analysis on "non-destructured" biofilm with Confocal Laser Scanning
Microscope combined with fluorescence staining.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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