Periodontitis Clinical Trial
Official title:
Platelet Rich Fibrin With 1% Metformin for the Treatment of Intrabony Defects in Chronic Periodontitis : A Randomized Controlled Clinical Trial
ABSTRACT:
Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which
releases various growth factors that promote tissue regeneration. Metformin (MF), a member
of biguanide group has been shown to facilitate osteoblast differentiation and thus may
exhibit a favourable effect on alveolar bone . Current study was designed to evaluate the
combined efficacy of PRF and 1% MF gel with open flap debridement (OFD) in treatment of
intrabony defects in chronic periodontitis (CP) subjects.
Methods: One hundred and twenty subjects with single defects were categorized into four
treatment groups: OFD alone, OFD with PRF, OFD with 1% MF and OFD + PRF+1% MF. Clinical
parameters like site specific plaque index (PI), modified sulcus bleeding index (mSBI),
probing depth (PD), relative attachment level (RAL) and gingival marginal level (GML) were
recorded at baseline before surgery and 9 months post-operatively. Percentage radiographic
intra-bony defect depth reduction was evaluated using computer-aided software at baseline
and 9 months.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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