Periodontitis Clinical Trial
Official title:
The Role of Macrophages in the Inflammatory Resolution Phase in Periodontal Patients
There is a growing body of evidence to suggest that the resolution of an inflammatory
reaction is an active process. This process requiring signals that turn off early
inflammatory stages, as neutrophil infiltration and promote resolution phase, as clearance
of apoptotic cells. In this array,the relationship between neutrophils, monocytes, and
macrophages is crucial for the concert process.
Macrophages possess a plasticity of phenotype that explains their protective as well as
potentially detrimental role in chronic inflammation and tissue injury. Such heterogeneity
arises as macrophages differentiate from monocytes and are exposed to specific tissue- and
hematopoietic cell-derived stimuli. It is important to be able to identify the different
types of macrophages in this setting. Today's literature can distinguish between 3 main
phenotypic groups of macrophages. The classically activated M1 macrophages, the
alternatively activated-M2 macrophages and the "resolution phase" - rMs macrophages. The
third phenotypic macrophage might play a crucial rule in the resolution phase, and is called
the "resolving macrophage".
All of those pro-resolving lipid mediators promote the return to tissue homeostasis .
The investigators hypothesis is that in periodontal patients the inflammatory process
continues because the process does not reach the resolution phase, and in that milieu, the
macrophage might be a key component.
Within the overall concept of periodontal disease as a model for an inflammatory disease
with an stoppable inflammatory reaction, the primary aim of the study is to check the
macrophage characteristics in periodontal patients and to compare it to healthy people.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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