Periodontitis Clinical Trial
Official title:
Impact of Periodontal Therapy on Endothelial Function
The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease
Periodontitis is one of the most prevalent chronic diseases and a frequent cause of tooth
loss. Accumulation of subgingival dental biofilm in susceptible individuals is associated
with an inflammatory host response characterized by the production of Matrix
Metalloproteinases, reduction in collagen synthesis, increase in cytokine gene expression,
and apoptosis of gingival fibroblasts. Finally, inflammation leads to destruction of
periodontal ligament, alveolar bone resorption, and chronic periodontitis.
Periodontitis is associated with increased serum levels of inflammatory cytokines and acute
phase reactants. Multiple case-control and cohort studies have suggested that periodontitis
is an independent risk factor for cardiovascular events, diabetic end-organ damage,
pregnancy complications and respiratory diseases. Recent interventional studies have found
that periodontal therapy could increase endothelium-dependent brachial artery flow-mediated
dilation.
The purpose of this controlled clinical trial is to determine the effect of periodontal
therapy on endothelial function in subjects with moderate to severe chronic periodontitis.
Furthermore, the relationship between putative periodontal pathogens and endothelial
function will be also evaluated.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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