Probiotics as Adjunct to Nonsurgical Periodontal Treatment

Status Completed

Clinical Trial Summary

ProlacSan probiotic lozenges and gels contain L. plantarum and L. brevis strains with proven in vitro antimicrobial activity against P. gingivalis. In our study we aim to investigate proposed benefit of ProlacSan as adjunct to conventional initial periodontal treatment in a group (n = 40) of Grade III and IV periodontitis patients. Patients will be randomized in two groups receiving either probiotic (n = 20) or placebo (n = 20) after completion of nonsurgical treatment within 7 days. Before treatment and after three months, standard periodontal parameters will be measured by masked examiner and plaque samples harvested for cultivation of 9 most relevant periodontal pathogens. One lozenge per day of probiotic/placebo will be used during 3 months healing period. Primary outcome measures will be the number of persisting sites per patient that need additional surgical treatment defined as sites with probing depth > 4 mm and bleeding on probing.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Periodontitis

Clinical Trial Details

NCT number	NCT04137419
Study type	Interventional
Source	University of Ljubljana
Contact
Status	Completed
Phase	N/A
Start date	November 11, 2018
Completion date	April 30, 2020

View Details

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