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Perihilar Cholangiocarcinoma clinical trials

View clinical trials related to Perihilar Cholangiocarcinoma.

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NCT ID: NCT06357117 Completed - Clinical trials for Perihilar Cholangiocarcinoma

Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma

Start date: April 13, 2018
Phase:
Study type: Observational

The extent of intrahepatic infiltration of perihilar cholangiocarcinoma (PHCC) remains unclear. This research aimed to explore the pattern and extent of intrahepatic infiltration of PHCC to guide surgical treatment and pathological research. This prospective study included 62 participants diagnosed with PHCC who underwent major hepatectomy. A whole-mount digital liver pathology system (WDLPS) for hepatectomy specimens greater than 10 × 10 cm was used to panoramically assess the intrahepatic infiltration extent of PHCC.

NCT ID: NCT06125769 Recruiting - Clinical trials for Perihilar Cholangiocarcinoma

LIver TrAnspLantation for Non-resectable Peri-HIlar cholangioCArcinoma (LITALHICA)

LITALHICA
Start date: January 15, 2024
Phase: N/A
Study type: Interventional

LITALHICA is a prospective non-randomized study aimed at exploring the outcome of liver transplantation in selected patients with unresectable perihilar cholangiocarcinoma (pCCA) after treatment with standard of care chemotherapy, in terms of overall survival and quality of life. Additionally, the study aims to identify pre-transplant biological markers and clinical factors that can stratify patients with the best post-transplant prognosis. Finally, the study aims to investigate the role of preoperative PET-MRI, especially in relation to lymph node locations, by correlating the results with histological examination after hilar lymphadenectomy.

NCT ID: NCT05874934 Recruiting - Clinical trials for Perihilar Cholangiocarcinoma

Endoscopic Drainage of Presumed Resectable pCCA Using an Intrahepatic Plastic Stent With Retrieval String

CHORDA-II-p
Start date: March 1, 2023
Phase: N/A
Study type: Interventional

Prospective pilot study to assess the feasibility and efficacy of intrahepatic plastic biliary stents with a retrieval string in patients with presumed resectable perihilar cholangiocarcinoma requiring biliary drainage of the future liver remnant.

NCT ID: NCT05563870 Active, not recruiting - Clinical trials for Perihilar Cholangiocarcinoma

Endoscopy and Radiology-guided Ablation for Inoperable Cholangiocarcinoma

COMBO-RFA
Start date: August 1, 2022
Phase: N/A
Study type: Interventional

This prospective clinical trial aims to assess the feasibility, efficacy, and safety of a personalized radiofrequency ablation protocol coupled with complete biliary drainage for patients presenting with inoperable perihilar cholangiocarcinoma.

NCT ID: NCT05546372 Recruiting - Clinical trials for Perihilar Cholangiocarcinoma

Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction Due to Perihilar Cholangiocarcinoma

RACCOON
Start date: November 9, 2023
Phase: N/A
Study type: Interventional

A multicentre, parallel group, open label, randomized controlled trial comparing endobiliary RFA prior to metal stent placement with stent placement only in patients with inoperable perihilar cholangiocarcinoma.

NCT ID: NCT05430698 Recruiting - Clinical trials for Perihilar Cholangiocarcinoma

PD-1 Antibody Plus GEMOX as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma

Start date: January 31, 2023
Phase: Phase 2
Study type: Interventional

This is an open-label,single center,non-randomized,single arm exploratory study. The objective of this study is to evaluate the efficacy and safety of PD-1 antibody plus GEMOX as postoperative adjuvant therapy in perihilar cholangiocarcinoma with positively metastatic lymph nodes.

NCT ID: NCT05402618 Completed - Clinical trials for Perihilar Cholangiocarcinoma

Minimally Invasive Versus Open Surgery for PHC

Start date: May 1, 2018
Phase:
Study type: Observational

Brief Summary: This is a multicentric, retrospective, real-world study to investigate the surgical outcomes of minimally invasive surgery compared with open surgery for Perihilar Cholangiocarcinoma (PHC), with the perioperative characteristics and long-term overall survival being compared. We aimed to find out whether the minimally invasive surgery is safe or feasible for PHC. And we also want to find out patients with what kind of characteristic can be benefit from the minimally invasive surgery compared with the open approach.

NCT ID: NCT05078801 Active, not recruiting - Clinical trials for Jaundice, Obstructive

Endoscopic Versus Radiologic Biliary Drainage for Perihilar Malignant Obstruction

Start date: July 15, 2021
Phase:
Study type: Observational

This retrospective monocentric study aims at comparing multimodality endoscopic biliary drainage versus percutaneous radiologic biliary drainage in case of perihilar malignant obstruction. Data from patients admitted in the Nancy University Hospital, France, between january 2016 and march 2022 with jaundice and perihilar obstruction will be retrospectively collected.

NCT ID: NCT05024513 Recruiting - Clinical trials for Perihilar Cholangiocarcinoma

Biliary Drainage Plus HAIC in Locally Advanced pCCA

Start date: November 1, 2021
Phase: Phase 2
Study type: Interventional

Biliary drainage and stent placement remains to be the main palliative treatment choice for advanced perihiliar cholangiocarcinoma (pCCA), and the life expectancy is only 4-6 months. Previous single center prospective phase 2 trial showed that hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin and 5-fluorouracil was an encouraging treatment choice for advanced pCCA due to its high tumor control, survival benefit, and low toxicity. Thus, the multicenter prospective controlled trial was designed to explore and confirm the survival benefit of biliary drainage plus hepatic arterial infusion chemotherapy with oxaliplatin and 5-fluorouracil compared with biliary drainage plus best support care treatment in locally advanced pCCA patients.

NCT ID: NCT04993131 Recruiting - Bile Duct Cancer Clinical Trials

Liver Transplantation for Non-resectable Perihilar Cholangiocarcinoma

TESLA II
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The study will investigate whether liver transplantation provides increased survival, low side effects and good quality of life in patients with bile duct cancer where the tumor cannot be removed by normal surgery. Analyzes of blood and tissue samples from the tumor will be investigated to see if the analyzes can indicate who may have recurrence of the disease after liver transplantation. Furthermore, the effect of chemotherapy on normal liver and tumor tissues in the liver that are removed during transplantation will be investigated.