Periapical Periodontitis Clinical Trial
Official title:
Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
The purpose of the study is to investigate the effect of injectable platelet rich fibrin augmented with Vitamin C (ascorbic acid) in healing of chronic peri-apical lesion, by assessing it radiographically 2dimensionally and 3 dimensionally
all patients will be informed about the study through informed constant that will describe the natural of the study beside the potential risks of it. After accurate diagnosis clinically and radiographically, patients who will meet the eligibility criteria will be randomized. The standardized operating procedure of regenerative therapy requires two treatment visits. During the first appointment, infection is controlled and inflammation is relieved. Regenerative procedure and revascularization are accomplished during the second appointment. At the first visit, perioperative CBCT will be taken, access cavity with full mechanical preparation will be accomplished followed by application of double biotics paste for 3 weeks. At the second appointment the intra-canal medicaments will be removed then 10 ml of blood of whole venous blood will be drawn from the patient's forearm and transferred into two plain plastic test tubes without an anticoagulant and will centrifuge immediately u at 700 rpm for 3 minutes then liquid platelet rich fibrin layer will be taken with plastic syringe and according to the group of the patient that will be assigned, the patient will receive either the iprf alone or to be mix with Vitamin C and injected inside the canal. Collagen membrane will be placed over the iprf or iprf with Vitamin C then the tooth will be restored with resin filling material, the patients will be followed every 3 months for 1 year, at every follow up periapical radiograph will be taken with standardized bite block and after 1 year CBCT will aslo be taken with same parameter of the perioperative one t be compared and asses the reduction of the periapical lesions ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03102879 -
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
|
N/A | |
Completed |
NCT00226148 -
Immediate Implant Placement in the Molar Regions
|
Phase 0 | |
Completed |
NCT05718596 -
Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
|
N/A | |
Recruiting |
NCT00762840 -
Safety and Efficacy of the Apexum Ablator
|
N/A | |
Recruiting |
NCT05525013 -
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
|
N/A | |
Active, not recruiting |
NCT05555043 -
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
|
N/A | |
Recruiting |
NCT06322979 -
Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth
|
N/A | |
Completed |
NCT02947763 -
Single Versus Multiple Visits Endodontic Treatment
|
Phase 1 | |
Completed |
NCT05857436 -
Relationship Apical Periodontitis and the Main Bacterial Species in the Oral Microbiota
|
N/A | |
Active, not recruiting |
NCT03660163 -
Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.
|
||
Completed |
NCT02801552 -
Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
|
N/A | |
Completed |
NCT02632513 -
Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment
|
N/A | |
Completed |
NCT01312194 -
Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients
|
N/A | |
Completed |
NCT00223327 -
Measurement of Bite Force in Humans
|
Phase 0 | |
Completed |
NCT05297747 -
Adrenomedullin Upregulation in Apical Periodontitis
|
N/A | |
Completed |
NCT03708081 -
Comparative Evaluation of Different File Systems in Postoperative Pain
|
||
Recruiting |
NCT01799187 -
Research of Revascularization in Immature Teeth With Periapical Periodontitis
|
N/A | |
Completed |
NCT06023901 -
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
|
N/A | |
Completed |
NCT02747082 -
Antibacterial Effectiveness of Two Root Canal Irrigants
|
Phase 2 | |
Completed |
NCT06339905 -
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
|
N/A |