Association of Intestinal Microbiota and the Onset of Perianal Abscess Based on 16S rDNA Amplicon Sequencing

Perianal Abscess Clinical Trial

Official title:

Association of Intestinal Microbiota and the Onset of Perianal Abscess Based on 16S rDNA Amplicon Sequencing

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05862129
• Other study ID #: 2022SF-369
• Status: Not yet recruiting
• Start date: May 10, 2023
• Est. completion date: December 2024

Study information

• Verified date: May 2023
• Source: Xi'an Hospital of Traditional Chinese Medicine
• Contact: Sun Xingwei
• Phone: +8613571818516
• Email: 4866442[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is tolearn the association of gut microflora with the onset of perianal abscesses. The main questions it aims to answer are:

Question 1: To understand the structure of rectal microbial community composition and its relationship with pathogenic bacteria in patients with perianal abscess.

Question 2: Understand the structure of rectal microbial community composition in healthy people.

Participants will be collected with rectal secretions and stool specimens.In addition, patients with perianal abscess should also collect pus samples.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: December 2024
• Est. primary completion date: December 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Observation group: ? Age between 18-60 years, local resident of Xi'an; ? met the diagnostic criteria for perianal abscess and underwent surgical treatment in our hospital; ? did not use antibiotics before treatment; ? himself and his family members were willing to participate in this study and signed informed consent.

Control group: ? Age between 18-60 years, permanent residents in Xi'an; ? had no serious chronic disease, no abnormality in physical examination in the last 1 week; ? did not use drugs that may affect intestinal flora in the last one month; ? himself and his family members are willing to participate in the study and sign the informed consent.

Exclusion Criteria:

• Failing to retain the specimens as required

Related Conditions & MeSH terms

• Abscess
• Perianal Abscess

Intervention

Procedure:
• surgical operation
Radical operation for the perianal abscess

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Xi'an Hospital of Traditional Chinese Medicine

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Observation group: the structure and changes of rectal flora before and after treatment	Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing	Two months
Primary	Control group: the structure and changes of rectal flora in healthy population	Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing	Two months