Effect of Repeated Removal and Re-placement of Abutments Around Dental Implants

Peri-implant Mucositis Clinical Trial

Official title: Effect of Repeated Removal and Re-placement of Laser Microgrooved and Machined Abutments on Proinflammatory Cytokine Levels Around Dental Implants

Status Recruiting

Clinical Trial Summary

Repeated removal and re-placement of healing and prosthetic abutments result in frequent injuries to the soft tissues. The purpose was to evaluate the effect of repeated removal and re-placement of laser microgrooved and smooth/machined healing and prosthetic abutments during restorative stages, and 1 year after functional loading, on proinflammatory cytokine levels around dental implants.

Clinical Trial Description

Twenty-four patients each received 2 one-stage implants in a split mouth design on the same jaw. In each patient one healing and prosthetic abutments with a laser microgrooved surface (LMS group) and one healing and prosthetic abutments with smooth/machined surface (S/MS group) were used. Four months following implant placement [Baseline (BSL)], the healing abutments were disconnnected and reconnected three times to carry out the impression procedures and metal framework try-in. Four weeks later (T0), definitive prosthetic abutments were installated with screw retained crowns. Samples for immunological analyses were taken from the sulcus around each implant at BSL, T0, and 1 year after functional loading (T1). Peri-implant crevicular fluid samples were analyzed for interleukin-1beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α levels using the ELISA kit. ;

Related Conditions & MeSH terms

• Mucositis
• Peri-implant Mucositis

• NCT number: NCT04415801
• Study type: Interventional
• Source: University of Roma La Sapienza
• Contact: Renzo Guarnieri, MD DDS
• Phone: +39 3425224458
• Email: renzoguarnieri@gmail.com
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2020
• Completion date: May 31, 2020