Peri-Implantitis Clinical Trial
Official title:
Metabolomic and Proteomic Fingerprinting in Peri-implant Diseases
Due to the limited efficacy of its treatment modalities, there is a stringent need to improve the prevention and early diagnosis of peri-implantitis. In fact, to date clinical and radiographic tools are not able to discern which patients are going to develop peri-implantitis and, among the ones already with peri-implantitis, which ones are currently loosing bone and which ones are going to progress. This project aims to analyze for the first time the whole large scale proteome and metabolome of peri-implant crevicular fluid (PICF) with an integrated approach from implants with peri-implant diseases. Twenty-five patients with at least one implant with peri-implant mucositis and one implant with peri-implantitis will be selected. For each of the selected participants, the PICF from an implant with peri-implant mucositis and from an implant with peri-implantitis will be sampled two different times before treatment. One year after the corresponding treatment is provided, the PICF of the treated implants with peri-implantitis will be sampled again. Both proteomic and metabolomic profiling of the samples will be carried out. The most important strength of this project will be the ability to evaluate together the whole proteome and the whole metabolome and to integrate them in the same framework.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05332327 -
Comparison of the Accuracy of Different Periodontal Probes for Peri-implant Pocket Registration
|
||
| Enrolling by invitation |
NCT06063876 -
Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty
|
N/A | |
| Completed |
NCT04249024 -
Peri-implantitis, Comparing Treatments 970 nm Laser and Mucosal Flap Surgery
|
N/A | |
| Withdrawn |
NCT03624257 -
Comparing Two Treatment Modalities of Peri-implantitis - Blue Laser (445 nm) and Conventional Flap Surgery
|
N/A | |
| Completed |
NCT03157193 -
Effect of Hyaluronic Acid on Perimplantitis
|
Phase 4 | |
| Completed |
NCT02375750 -
Treatment of Peri-implantitis Lesions by Using Biomaterial
|
N/A | |
| Completed |
NCT03018795 -
Ozone Therapy as an Adjunct to the Surgical Treatment of Peri-implantitis
|
N/A | |
| Enrolling by invitation |
NCT02575274 -
Peri-Implantitis Surgical Treatment an RCT Study
|
Phase 2/Phase 3 | |
| Completed |
NCT04833569 -
ICG-PDT, Periimplantitis, Diabetes Mellitus
|
Phase 1 | |
| Not yet recruiting |
NCT04337645 -
Resective Surgical Treatment of Peri-implantitis.
|
N/A | |
| Enrolling by invitation |
NCT06033859 -
Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
|
||
| Enrolling by invitation |
NCT05675241 -
Characterizing the Inflammation Around Dental Implants
|
||
| Recruiting |
NCT04983758 -
20-year Implant Survival in Periodontally Healthy and Compromised Patients
|
||
| Completed |
NCT04769609 -
Reconstructive Surgical Therapy of Peri-implantitis
|
||
| Completed |
NCT04874467 -
Influence of Keratinized Mucosa on Dental Implants With Mucositis
|
N/A | |
| Not yet recruiting |
NCT04323540 -
Treatment of Peri-implantitis With or Without Simultaneous Soft Tissue Augmentation
|
N/A | |
| Completed |
NCT05724706 -
An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
|
||
| Completed |
NCT04559841 -
Regenerative Surgical Treatment of Peri-implantitis Using Nanobone With or Without Simvastatin
|
N/A | |
| Recruiting |
NCT05906810 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis
|
N/A | |
| Completed |
NCT05595746 -
Radiological Bone Loss on Different Levels of Dental Implants
|
N/A |