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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00528138
Other study ID # HLS-0045-07-07
Secondary ID
Status Completed
Phase N/A
First received September 10, 2007
Last updated November 9, 2009
Start date October 2007
Est. completion date September 2008

Study information

Verified date November 2009
Source Cirujanos la Serena
Contact n/a
Is FDA regulated No
Health authority Chile: Instituto de Salud Pública de Chile
Study type Observational

Clinical Trial Summary

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.

The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis.

The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.


Description:

- Previously validated appendicitis score

- Time from onset of symptoms to diagnosis and to surgery

- Laboratory values: WBC, CRP, liver function test

- SIRS values

- Preoperative and postoperative diagnosis

- Length of hospital stay

- Postoperative complications

- Biopsy results


Recruitment information / eligibility

Status Completed
Enrollment 132
Est. completion date September 2008
Est. primary completion date September 2008
Accepts healthy volunteers No
Gender Both
Age group 15 Years and older
Eligibility Inclusion Criteria:

- Patients scheduled for appendectomies for acute appendicitis at the emergency unit of our institution

- Patients older than 15 years of age to 100 years of age

Exclusion Criteria:

- Appendectomy performed incidentally or for other indications

- Patients younger than 15 years of age

- Alcoholism

- A history of viral hepatitis

- Gilbert's disease

- Dubin Johnson syndrome

- BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary

- Hemolytic or liver diseases associated with hyperbilirubinaemia

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Other:
Laboratory Test
CRP, white blood cell count, hepatic function tests

Locations

Country Name City State
Chile Hospital De La Serena - Emergency Unit La Serena IV Region

Sponsors (1)

Lead Sponsor Collaborator
Cirujanos la Serena

Country where clinical trial is conducted

Chile, 

See also
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Terminated NCT00540189 - Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children N/A
Completed NCT00677417 - Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis N/A
Terminated NCT03795194 - Antibiotic Duration in Post-appendectomy Abscess Phase 4
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Completed NCT02881996 - The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis N/A
Active, not recruiting NCT04039750 - Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis Phase 2
Completed NCT02724410 - Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis N/A
Recruiting NCT04253899 - The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations N/A
Completed NCT00854815 - Irrigation Versus No Irrigation for Perforated Appendicitis N/A
Completed NCT00195923 - Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis Phase 4
Withdrawn NCT00879294 - The Effect of Gum Chewing on Postoperative Ileus N/A