Clinical Trials Logo

Clinical Trial Summary

The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated appendicitis compared to suction without irrigation. This will be the first prospective study to compare these two options in pediatric PA.


Clinical Trial Description

This study is for pediatric patients who are having an appendectomy and have a perforated appendix. The purpose of this study is to see whether antibiotic irrigation using gentamicin, clindamycin and suction during the surgery works better when compared to suction alone when cleaning the stomach cavity. Arm A patients will have their abdomen irrigated with the antibiotics, gentamycin and clindamycin, and then the wound will be suctioned out. Arm B patients will not have the antibiotic irrigation but will have their wound suctioned. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04039750
Study type Interventional
Source Prisma Health-Upstate
Contact
Status Active, not recruiting
Phase Phase 2
Start date July 25, 2019
Completion date December 2025

See also
  Status Clinical Trial Phase
Completed NCT04512196 - Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution N/A
Not yet recruiting NCT03267082 - Evaluation the Role of Laparoscopic Management of Perforated Appendicitis N/A
Completed NCT00528138 - Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation N/A
Completed NCT03289351 - Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis Phase 4
Recruiting NCT00677989 - Study on Laparoscopic Operation for Perforated Appendicitis N/A
Terminated NCT00540189 - Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children N/A
Completed NCT00677417 - Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis N/A
Terminated NCT03795194 - Antibiotic Duration in Post-appendectomy Abscess Phase 4
Completed NCT00462020 - Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis N/A
Completed NCT04472052 - Frequency of Perforated Appendicitis in Times of COVID-19
Completed NCT03159754 - Optimal Care of Complicated Appendicitis Phase 4
Completed NCT02881996 - The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis N/A
Completed NCT02724410 - Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis N/A
Recruiting NCT04253899 - The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations N/A
Completed NCT00854815 - Irrigation Versus No Irrigation for Perforated Appendicitis N/A
Completed NCT00195923 - Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis Phase 4
Withdrawn NCT00879294 - The Effect of Gum Chewing on Postoperative Ileus N/A