Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

Perforated Appendicitis Clinical Trial

Official title: Prospective Study Comparing Hyperbilirubinemia, CRP, White Blood Cell Count, and Other Clinical Parameters for the Preoperative Diagnosis of Perforated Acute Appendicitis

Status Completed

Clinical Trial Summary

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.

The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis.

The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

Clinical Trial Description

• Previously validated appendicitis score

• Time from onset of symptoms to diagnosis and to surgery

• Laboratory values: WBC, CRP, liver function test

• SIRS values

• Preoperative and postoperative diagnosis

• Length of hospital stay

• Postoperative complications

• Biopsy results ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Appendicitis
• Hyperbilirubinemia
• Perforated Appendicitis

• NCT number: NCT00528138
• Study type: Observational
• Source: Cirujanos la Serena
• Status: Completed
• Phase: N/A
• Start date: October 2007
• Completion date: September 2008