Duloxetine for the Treatment of Chronic Pelvic Pain

Pelvis Pain Chronic Clinical Trial

Official title: Evaluating Duloxetine's Analgesic Effectiveness in Chronic Pelvic Pain

Status Terminated

Clinical Trial Summary

This study is examining the effectiveness of duloxetine as a treatment for chronic pelvic pain in women. Duloxetine is FDA approved for the treatment of other pain conditions, including fibromyalgia and diabetic neuropathy.

Clinical Trial Description

Chronic pelvic pain in women can be caused by various pathologies, such as endometriosis, fibroids, and adhesions. Surgical treatment of the pathology often relieves the pain, but a significant number of women continue to have pain, even after visibly successful surgery. One model explored in this study is that in some cases of chronic pelvic pain, the central nervous system has changed in its processing of pain-related signals, requiring a therapy directed to the Central Nervous System (CNS) to effectively treat the pain. This model has been supported in studies of other chronic pain conditions, such as fibromyalgia and migraine. This study will seek to determine whether the analgesic effectiveness of duloxetine is related to the pain state of the individual. ;

Related Conditions & MeSH terms

• Pelvic Pain
• Pelvis Pain Chronic

• NCT number: NCT01451606
• Study type: Interventional
• Source: University of Maryland, Baltimore
• Status: Terminated
• Phase: Phase 4
• Start date: July 11, 2011
• Completion date: November 4, 2015