Pediatrics Clinical Trial
Official title:
Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias
Caudal analgesia with ropivacaine is commonly used in sub-umbilical pediatric surgery. However, increasing the dosage of ropivacaine has not been found to prolong the action significantly while complications will be serious. Ketamine as an additive to caudal administration had been shown to prolong the duration of postoperative analgesia, while the analgesic effectiveness of S-ketamine, the S(+)-enantiomer of ketamine with less possibility to induce psychomotor disturbances, is not clear. In this prospective randomized double-blind clinical trial , the investigators aimed to study the effect of S-ketamine as additive on the duration of caudal analgesia.
Forty-four children scheduled for hypospadias randomize into 2 groups. Group E (n=22) (0.2% ropivacaine 0.7 ml／kg and S-ketamine 0.5 mg/kg), group C(n=22)( 0.2%ropivacaine 0.7ml／kg and equivalent saline) intraoperative and postoperative hemodynamics will be recorded. Postoperative pain is assessed using an established 6-item FLACC score at 1h,3h,6h,12h,24h,48h, or the time when children complain of pain after surgery. A score of more15μg/kg is administered.Investigators propose to compare the duration of caudal analgesia provided by plain ropivacaine and by a mixture of ropivacaine and S-ketamine. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT05975658 -
WIReD: Wireless Interstage Remote Device Study
|
||
| Completed |
NCT03921346 -
Reducing Prehospital Medication Errors & Time to Drug Delivery by EMS During Simulated Pediatric CPR
|
N/A | |
| Completed |
NCT04301206 -
Videos and Simple Text to Empower Parents to Handle Their Sick Children
|
N/A | |
| Not yet recruiting |
NCT04087070 -
Blood Pressure Estimation Using Noninvasive Biosignals During Pediatric Anesthesia
|
||
| Recruiting |
NCT06273228 -
Parenting Young Children in Pediatrics
|
N/A | |
| Recruiting |
NCT05480930 -
Improving Nighttime Access to Care and Treatment; Part 4-Haiti
|
N/A | |
| Not yet recruiting |
NCT05815563 -
Validation of Peripheral Perfusion Index in Predicting Successful Supraclavicular Brachial Plexus Block in Pediatrics
|
||
| Recruiting |
NCT02908113 -
Visual Perception in Preterm Infants
|
N/A | |
| Recruiting |
NCT02556541 -
Ultrasound-guided Peripheral Vascular Access in Children
|
N/A | |
| Not yet recruiting |
NCT01678066 -
A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor
|
N/A | |
| Completed |
NCT04993599 -
Evaluation of Social Robot Usability for Pediatric Patients and Carers
|
N/A | |
| Completed |
NCT05537168 -
Bayesian Networks in Pediatric Cardiac Surgery
|
||
| Completed |
NCT01603628 -
BOTOX® Treatment in Pediatric Lower Limb Spasticity
|
Phase 3 | |
| Completed |
NCT01603615 -
BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity
|
Phase 3 | |
| Completed |
NCT06098105 -
Laparoscopic vs Ultrasound-Guided Transversus Abdominis Plane Block vs Laparoscopic Intraperitoneal Instillation of Local Anesthetic in Pediatrics
|
N/A | |
| Completed |
NCT01418846 -
Determination of Voriconazole Levels in Saliva - Validation in Specific Subsets of Patients
|
N/A | |
| Completed |
NCT01460329 -
Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO
|
N/A | |
| Withdrawn |
NCT00666393 -
An Evaluation of Safety of the Fentanyl Transdermal System for Management of Acute Post-Operative Pain in Pediatric Patients
|
Phase 3 | |
| Recruiting |
NCT03337581 -
Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric
|
Phase 4 | |
| Recruiting |
NCT05275881 -
Impact of Virtual Reality in Pediatric Hematology and Oncology
|
N/A |