Continuous Versus Bolus Administration of G-CSF in Children With Cancer

Status Recruiting

Clinical Trial Summary

The investigators hypothesized that in terms of granulocyte colony-stimulating factor (G-CSF) administration, the route of continuous infusion would lead to a faster neutrophil recovery compared to that of bolus administration

Clinical Trial Description

The investigators aimed to enroll 40 hospitalized patients in this phase 4 clinical trial. Patients with an ANC lower than 500 cells/mm3 will be randomly categorized into experimental and controlled arms. The experimental arm was designed to receive G-CSF intravenous infusion for 5 hours at a dose of 5 mcg/kg. The controlled arm was designed to receive a G-CSF bolus injection within one minute at a dose of 5 mcg/kg. Three days after treatment initiation, serum white blood cell and differential counts will be followed daily to determine the timing of steady neutrophil recovery. In the following time of another neutropenia event, the experimental arm would cross-switch to the controlled arm and receive corresponding G-CSF according to the study design ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06145321
Study type	Interventional
Source	Chang Gung Memorial Hospital
Contact	Yi-Lun Wang, Bachelor
Phone	0978989072
Email	mp2601@cgmh.org.tw
Status	Recruiting
Phase	Phase 4
Start date	November 23, 2023
Completion date	November 15, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04262830` - Cancer Therapy Effects on the Heart
Not yet recruiting	`NCT06335745` - PediCARE Health Equity Intervention in High-Risk Neuroblastoma	N/A
Withdrawn	`NCT04719416` - Relaxation Therapy in Pediatric Oncology	N/A
Completed	`NCT01645436` - Physical Activity in Pediatric Cancer (PAPEC)	N/A
Completed	`NCT04409301` - Distress in the Pediatric Oncology Setting: Intervention Versus Natural Adaptation	N/A
Completed	`NCT04914702` - Feasibility and Comparison of Continuously Monitored Vital Signs in Pediatric Patients With Cancer.
Recruiting	`NCT05425043` - Granulocyte Transfusions After Umbilical Cord Blood Transplant	N/A
Recruiting	`NCT05071859` - Genetic Overlap Between Anomalies and Cancer in Kids in the Children's Oncology Group: The COG GOBACK Study
Recruiting	`NCT03241251` - Screening for Psychosocial Risk in Flemish Families of a Child With Cancer
Recruiting	`NCT05384288` - Response to Influenza Vaccination in Pediatric Oncology Patients
Completed	`NCT04586491` - The Effect of Oral Care Protocol on Prevention of Oral Mucositis in Pediatric Cancer Patients	N/A
Recruiting	`NCT05569512` - Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML	Phase 1/Phase 2
Enrolling by invitation	`NCT05294380` - Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
Completed	`NCT02675166` - Getting Long-term Management of Adult Children Cured of Childhood Cancer in Rhône-Alpes
Completed	`NCT02665819` - Long Term Support for Pediatric Cancer Adult Survivors in Rhône-Alpes : Evaluation of Women Fertility.	N/A
Not yet recruiting	`NCT05454163` - Post-radiotherapy Rhinosinusitis in Children
Terminated	`NCT02536183` - A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors	Phase 1
Withdrawn	`NCT01828502` - Cotinine Feedback as an Intervention to Change Parental/Caregiver Smoking Behavior Around Children With Cancer	Phase 2
Completed	`NCT02032121` - Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors	N/A
Completed	`NCT03964259` - Reduced IV Fluids to Improve Clearance of HDMTX in Children w/Lymphoma or Acute Lymphoblastic Leukemia	Phase 1