PCOS Clinical Trial
Official title:
Role of Nesfatin-1 and Nicotinamide in Infertile Women With Polycystic Ovary Syndrome
evaluation of the potential role of circulating Nesfatin-1 and Nicotinamide in patients with
polycystic ovary syndrome.
and detection the correlation between Nesfatin-1 and body mass index (BMI), Waist hip ratio
(WHR), blood glucose, insulin, insulin resistance, lipid profiles, prolactin, LH, FSH,
estrogen, progesterone, testosterone and dopamine.
- Nesfatin-1 is an 82-amino acid polypeptide derived from the nucleobindin 2 (NUCB2)
precursor proteins.
- It is a newly identified peptide. It is released from several tissues including
forebrain, hindbrain, brainstem, spinal cord and adipose tissues.
- It plays an important role in hypothalamic pathways such as feeding inhibition,
locomotion, stress modulation, thermogenesis, and reproduction.
- Several studies had demonstrated that nesfatin-1 associated with body mass index (BMI),
insulin resistance and inflammatory response disorders.
- Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in
women. It is characterized by hyperandrogenism, multiple ovarian cysts,
oligomenorrhea/amenorrhea. Many mechanisms had been reported to be responsible for the
pathophysiology of PCOS. The condition is thought to be interactions between
hypothalamic-pituitary-ovarian, hypothalamic-pituitary-adrenal axis and metabolic
disorders.
- The circulating level of nesfatin-1 in PCOS patients is controversial. Some studies
reveal lower nesfatin-1 serum levels while others reveal higher level.
- Women with PCOS may have reduced dopamine production from the hypothalamus and elevated
prolactin concentrations and this mechanism may be responsible for reproductive
disorder.
- In PCOS, stimulation of reactive oxygen species (ROS) generation from mononuclear cells
(MNCs) by hyperglycemia . The superoxide radical in particular is a ROS that is
generated by the activity of membrane-bound nicotinamide adenine dinucleotide phosphate
(NADPH) oxidase.
- Dopaminergic (DA) neurons are highly susceptible to ROS. DA is relatively unstable
molecule and undergoes auto-oxidative metabolism in nigro striatal tract system, leading
to ROS production. Nicotinamide can reduce hypothalamic dopamine in postnatal brains
results in dopamine-deficient phenotypes. Nicotinamide prevents DA release induced by
long-term perinatal asphyxia.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06101147 -
Effect of Vitamin D Supplementation on Testosterone Level in Women With Polycystic Ovary Syndrome
|
Phase 2 | |
| Completed |
NCT02037672 -
PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome
|
Phase 4 | |
| Completed |
NCT01833949 -
Unilateral Laparoscopic Diathermy Adjusted to Ovarian Volume
|
N/A | |
| Completed |
NCT03608813 -
Myo-inositol, D-chiro-inositol and Glucomannan in PCOS
|
||
| Not yet recruiting |
NCT05298657 -
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
|
||
| Completed |
NCT05951309 -
Myoinositol Treatment and Asprosin Levels in PCOS
|
N/A | |
| Enrolling by invitation |
NCT04485403 -
The Effect of Ibuprofen on Women With PCOS.
|
Phase 2 | |
| Not yet recruiting |
NCT03978013 -
Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
|
N/A | |
| Recruiting |
NCT03767569 -
Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients
|
Phase 3 | |
| Completed |
NCT05843955 -
Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome
|
||
| Recruiting |
NCT05971849 -
Dampening the Reproductive Axis With Continuous Kisspeptin
|
Phase 1 | |
| Recruiting |
NCT04597099 -
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
|
Early Phase 1 | |
| Active, not recruiting |
NCT05206448 -
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
|
Phase 4 | |
| Recruiting |
NCT02358421 -
Prediction of High Ovarian Response After Assisted Reproductive Techniques
|
N/A | |
| Completed |
NCT04113889 -
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome
|
Phase 2 | |
| Completed |
NCT04562883 -
Single vs. Group CAPA-IVM Culture of Cumulus-oocyte Complexes
|
N/A | |
| Recruiting |
NCT03264638 -
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
|
Phase 2 | |
| Completed |
NCT00594217 -
Determining How Quickly Progesterone Slows LH Pulse Frequency
|
Phase 1 | |
| Recruiting |
NCT02024984 -
Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial
|
Phase 1 | |
| Completed |
NCT01709942 -
Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)
|
Phase 3 |