Pathological Gambling Clinical Trial
Official title:
The Role of Neuromodulation for Cognitive Processing and Behavioural Inhibition in Gambling Disorder
Gambling disorder is associated to high impulsivity and excessive risk-taking behaviour.
These behavioural characteristics related to addiction are linked to cognitive processes in
specific brain areas located in the prefrontal cortex (PFC).
With the aim of studying the role of PFC in gambling disorder, the investigators employ
transcranial current direct stimulation (tDCS), a noninvasive brain stimulation technique
that applies a very weak electrical current to the superficial areas of the brain.
The clinical phase of the research consists on studying the effects of tDCS in combination
with cognitive behavioural therapy (CBT) in patients that attend the United Kingdom (UK)
National Problem Gambling Clinic. The main objective of the project is to investigate whether
the combination of tDCS and CBT can help to decrease impulsivity and risk-taking behaviour
and therefore improve the treatment for gambling disorder.
The investigators aim to have a total of 32 participants diagnosed with gambling disorder
with the Problem Gambling Severity Index (PGSI). There will be 16 participants per group
having two different groups (real stimulation and sham). Real stimulation involves the
application of tDCS stimulation and sham condition is used as a control (similar to a
placebo).
Participants will attend 8 weekly sessions where they receive tDCS stimulation for 20
minutes, while complete CANTAB cognitive tasks that measure cognitive processes such us
control inhibition and risk-taking behaviour. Electroencephalography (EEG) activity will be
measured before and after tDCS.
Participants will also complete cognitive questionnaires (Pathological Gambling adapted
Yale-Brown Obsessive Compulsive Scale (PG-YBOCS), Gambling Symptom Assessment Scale (G-SAS)
and Visual Analogue Scale (VAS) for gambling cravings.
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