Parkinson Clinical Trial
Official title:
EMG Modules as a Novel Biomarker of Basal Ganglia Plasticity in Parkinson's Disease
Study Purpose: Parkinson's disease leads to severally impaired motor control. The purpose of this study is to better understand and analyze the characteristics of arm muscle activity while doing some reaching tasks and of leg muscles while walking. This will allow the investigators to improve understanding of the mechanisms underlying the motor impairments in Parkinson's disease.
More details: A total of 20 participants with Parkinson's disease and 20 age- and gender-matched healthy controls will be included in this study. The participants with Parkinson's disease should have symptoms only on one side of the body, and they should not be taking any dopamine replacement medication such as levodopa or dopamine agonists. The study will take place at the Motion Analysis Laboratory of Spaulding Rehabilitation Hospital in Charlestown, Massachusetts. It will consist of two assessment sessions; one where muscle activity of the arms as well as movement characteristics will be assessed during a reaching task; and another where muscle activity of the legs and movement characteristics will be assessed while walking on a treadmill. Clinical evaluations will also be performed. In addition, individuals with Parkinson's disease will undergo brain scans at Massachusetts General Hospital to examine whether there are any relationships between muscle activity and brain function. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06037590 -
A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops™ Relative to INBRIJA®
|
Phase 1 | |
| Recruiting |
NCT01537224 -
Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information
|
N/A | |
| Withdrawn |
NCT04011449 -
State-dependent Pathophysiological Oscillations in Parkinson's Disease and Treatment With DBS Using the Medtronic RC+S
|
N/A | |
| Completed |
NCT02539446 -
Suprapostural Attention Focus and Postural Difficulty on H-reflex and Brain Activity: Aging and Parkinson's Disease
|
N/A | |
| Completed |
NCT00358189 -
Effects of Deep Brain Stimulation for the Treatment of Parkinson's Disease
|
N/A | |
| Active, not recruiting |
NCT04606979 -
tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
|
N/A | |
| Completed |
NCT05119803 -
The Relationship of Spine Posture and Mobility With Upper Extremity Functions in Parkinson's Patients
|
||
| Recruiting |
NCT06154772 -
Quality of Life, Anxiety and Fatigue Level of Parkison's Patients With Color Therapy
|
N/A | |
| Not yet recruiting |
NCT02249715 -
Development of a Monitoring Set-up and Algorithm Using Functional MRI (fMRI) and EEG for Prediction of Response to Repetitive Deep Transcranial Magnetic Stimulation (rDTMS) for Patients With Parkinson's Disease
|
N/A | |
| Completed |
NCT01732653 -
A Treadmill Training Program Augmented by Virtual Reality to Decrease Fall Risk in Older Adults
|
N/A | |
| Completed |
NCT03232996 -
Evaluation of a Computer Game Based Rehabilitation System for Assessment and Treatment of Balance and Gait Impairments in Individuals With Parkinson's Disease.
|
N/A | |
| Enrolling by invitation |
NCT04566341 -
Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease
|
||
| Active, not recruiting |
NCT04978597 -
Early ParkinSon wIth L-DOPA/DDCI and OpicapoNe (EPSILON Study)
|
Phase 3 | |
| Recruiting |
NCT06116084 -
Randomized Controlled Study Evaluating the Efficacy of Hypnosis in Nuclear Medicine
|
N/A | |
| Recruiting |
NCT05830396 -
GRoningen Early-PD Ambroxol Treatment
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT05379062 -
Choral Singing for Patients With Parkinson's
|
N/A | |
| Completed |
NCT02071823 -
Comparative Bioavailability Study of BIA 9-1067 25 mg Capsules
|
Phase 1 | |
| Recruiting |
NCT03558568 -
The Effect of Deep Brain Stimulation on Facial Expressions.
|
N/A | |
| Enrolling by invitation |
NCT05596201 -
Super-resolution of Brain Magnetic Resonance Images in Deep Brain Stimulation for Parkinson's Disease
|
||
| Recruiting |
NCT04181918 -
Action Observation Treatment in Parkinson's Patients
|
N/A |