Parkinson's Clinical Trial
— ApoDOfficial title:
Detection of Apolipoprotein D (ApoD) in Human Serum as Marker of Parkinson's Disease
Verified date | September 2013 |
Source | Privatklinik Villa Melitta |
Contact | n/a |
Is FDA regulated | No |
Health authority | Italy: National Institute of Health |
Study type | Observational |
In Italy affected people are 200,000 and every year Parkinson new cases are 10,000. Aging is
the principle risk factor of Parkinson with the possibility of its development doubling
every five years after 65. Because of the increase of the social longevity and aging as the
main risk factor, there are many repercussions on the health system (hospital stays and
pharmaceutical costs) as on the social system (assistance- related problems). Parkinson's
disease exerts an extremely negative impact on life's quality of the patient. In fact,
because of Parkinson symptoms (tremor, dribble, etc), patient's social life will be reduced
with the consequent development of the depression. Consequently, the early detection and
treatment of Parkinson's is necessary.
To achieve this goal, Apolipoprotein D (ApoD) in human serum as a marker of the oxidative
stress-inflammation vicious cycle seems most promising candidate for diagnosis.
Status | Enrolling by invitation |
Enrollment | 180 |
Est. completion date | November 2013 |
Est. primary completion date | June 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Patients with Parkinson's disease in the pathological related stages (Hoehn and Yahr) - Persons > 20 years Exclusion Criteria: - Patients with a neurodegenerative disorder different to Parkinson's disease - Patients, who are post-ictus and/or traumatic brain injury (TBI) - Patients, who are treated with antipsychotic drugs - Obese persons (BMI > 27) - Idiopathic normal pressure idrocephalus (INPI) - Paget's disease - Breast cancer - Adenocarcinoma of the prostate - Glucose-6-phosphate (GSD-I) deficiency - Insuline-resistance-related disorders |
Observational Model: Cohort
Country | Name | City | State |
---|---|---|---|
Italy | Privatklinik Villa Melitta | Bozen | Südtirol |
Lead Sponsor | Collaborator |
---|---|
Privatklinik Villa Melitta |
Italy,
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* Note: There are 12 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Detection of Apolipoprotein D | Apolipoprotein D (apoD)concentration in human serum as a potential marker for Parkinson's disease (PD) | Baseline | Yes |
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