Papillary Thyroid Carcinoma Clinical Trial
Official title:
Immunohistochemical Detection of the BRAFV600E Mutation on Cytological Specimen in PTC
Immunohistochemical detection of the BRAF-V600E mutation on pre-operative fine needle aspiration biopsy (FNAB) from patients suspected for papillary thyroid carcinoma, using the mutation specific antibody VE1.
The BRAF mutation is reported to be present in approximately 50% of papillary thyroid
carcinomas (PTC). The mutation has been associated with poor prognosis and more advanced
disease stage. Therefore, pre-operative detection of the BRAF-V600E mutation may be of
clinical interest in order to individualize treatment of patients with BRAF positive PTC.
FNABs are performed immediately before the thyroid operation, and BRAF-V600E detection using
VE1 is performed on clots. The VE1 stain is compared to the mutation status of the removed
cancer or control tissue using the Cobas test.
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