Papillary Thyroid Carcinoma Clinical Trial
Official title:
APPLICATION OF MOLECULAR TECHNIQUES FOR IMPROVING THE DIAGNOSIS AND TREATMENT OF NODULAR THYROID LESIONS.
To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System)
Aim of the study To determine the improvement in diagnosis of papillary carcinoma by
detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis
(categories III, IV and V of Bethesda System).
Design: Retrospective observational study. Scope: The study will be peformed at the
Pathology Service, from cytological samples and paraffin file post-diagnosis. Mutations are
detected by pyrosequencing technique.
Subject of study:
Cases with histological diagnosis of papillary carcinoma (CP) and previous cytological
diagnosis in groups III, IV and V Bethesda, collected between October 1989 and July 2014 in
Corporació Parc Taulí.
Methodology:
- Identification of cases
- Detection of BRAF V600E mutation, initially in histological material from the surgical
specimen, and if present, detection in cytological material.
The statistical analysis will use SPSS. Univariate and bivariate analysis will be done.
Results will be presented in the form of frequency tables and percentages for qualitative
variables and by average, median and standard deviation for quantitative variables. Pearson
chi-square or Fisher's exact test will be applied. The Student t test or the Mann-Whitney
test will be performed for quantitative variables.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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