Panic Disorder Clinical Trial
OBJECTIVES: I. Determine whether the benzodiazepine alprazolam reinforces self-medication
behavior in anxious patients with varying histories of using other drugs.
II. Establish outpatient methods for the study of self-medication and drug reinforcement in
patients vulnerable to prescription drug abuse or dependence.
III. Evaluate the influence of alcohol and other non-prescription drug use as determinants
of vulnerability in these patients.
IV. Identify personality, attitudinal, or other variables that might predict different
patterns of self-medication.
V. Assess the effects of cognitive-behavioral therapy on alprazolam self-medication.
PROTOCOL OUTLINE: This protocol involves different experiments examining self-medication
with anxiolytic medications in selected patients, and cognitive-behavioral therapy for
anxiety. Capsules are color coded and taken under double-blind conditions. Compliance is
monitored with the Medication Event Monitoring System, which automatically registers the
date and time each bottle is opened.
The physician directs therapy administration, using some combination of the following: blind
choice test, antianxiety agent(s), placebo, and cognitive-behavioral therapy.
;
Primary Purpose: Treatment
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