Pancreatic Ductal Adenocarcinoma Clinical Trial
Official title:
Prognostic Value of Quantitative p63 Immunostaining in Adenocarcinoma of Lung, Breast, and Pancreas
The p63 gene is a recently discovered member of the p53 family located at chromosome
3q27Many studies have reported that overexpression of p63 can mimic p53 activities by
binding DNA, activating transcription, and inducing apoptosis.
Various studies proved p63 as a marker of basal cells in normal salivary glands, breast,
prostate, respiratory and squamous epithelia, and of tumor cells from various malignancies.
Still, p63 has been the subject of relatively few studies in lung adenocarcinoma, and breast
carcinoma, and no study has described the correlation of p63 with pancreatic ductal
adenocarcinoma.
In the current study, we aim to evaluate the prognostic value of the expression of p63 in
the lung adenocarcinoma, breast adenocarcinoma, and pancreatic ductal adenocarcinoma. We
will achieve this aim by collecting clinical data retrospectively from the patients' medical
records as well as assessing the histological sections and performing immunohistochemical
staining for p63.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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