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NCT number NCT03198871
Study type Interventional
Source University of Pittsburgh
Contact Amy Monroe
Phone 412-623-6382
Status Not yet recruiting
Phase Phase 3
Start date January 1, 2018
Completion date November 15, 2018

Clinical Trial Summary

The primary goal of this study is to assess the utility of a postoperative intravenous acetaminophen dosing schedule in minimizing postoperative pain, opioid consumption and opioid-related side effects. Investigators also aim to study overall patient satisfaction and cost-effectiveness (direct and indirect costs) of this regimen as part of Enhanced Recovery After Surgery protocol at the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital, a tertiary care hospital and level one trauma center.

Clinical Trial Description

In response to an increased focus on improving patient outcomes and satisfaction with surgical care, a growing body of clinical evidence has recently been dedicated to enhanced recovery after surgery (ERAS) protocols. These evidence-based perioperative pathways aim to optimize patients undergoing surgery in the preoperative, intraoperative, and postoperative periods. Intravenous acetaminophen has been of interest for its utility in post-surgical patients, who have not yet been cleared for oral intake. Intravenous acetaminophen should also be preferred over oral acetaminophen in patients after major abdominal surgery where absorption of medications given through oral route is erratic. For this trial, patients will be randomized to receive a regimented IV acetaminophen or placebo dose in addition to standard of care opioids for pain control following abdominal procedures.

Study Design

Related Conditions & MeSH terms

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