Pancreatic Cancer Clinical Trial
— LIQUIPANCOfficial title:
Liquid Biopsy Guided Treatment in Localized Pancreatic Cancer (LIQUIPANC): Circulating Tumor DNA (ctDNA) as Precision Medicine Tool for Stratification of Neoadjuvant Chemotherapy vs. Upfront Surgery
This study evaluates the clinical prognostic impact (on DFS and OS) of liquid biopsy guided treatment vs. standard of care (physicians choice) in localized pancreatic cancer (despite because of CA 19-9 levels and computed tomography, upfront surgery is recommended by tumor board). ctDNA positive patients will receive neoadjvuant chemotherapy at current gold standard physicians choice instead of upfront surgery, because of assumed high biological risk for early recurrence.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 31, 2026 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - Informed consent - >18 years old - localized pancreatic cancer to go for upfront surgery Exclusion Criteria: - synchronous secondary malignancy - pregnancy |
Country | Name | City | State |
---|---|---|---|
Austria | Ordensklinikum Linz Barmherzige Schwestern | Linz | Upper Austria |
Lead Sponsor | Collaborator |
---|---|
Elisabethinen Hospital | Medical University Innsbruck |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | DFS | Disease free survival | After 12 months | |
Secondary | OS | Overall survival | After 12 months | |
Secondary | ctDNA detection rate | Detection rate of ctDNA in peripheral blood using a cost-effective and clinical applicable small spectrum ddPCR analysis in order to enable immediate clinical implementation | Preoperatively |
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