Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery

Status Recruiting

Clinical Trial Summary

This is a randomized phase 1 clinical trial to evaluate the safety of an optimized neoantigen synthetic long peptide (SLP) vaccines in pancreatic cancer patients following neoadjuvant chemotherapy. The neoantigen SLP vaccines will incorporate prioritized neoantigens and will be co-administered with poly-ICLC. Patients will be randomized to one of two arms: Arm 1 (neoantigen vaccine following neoadjuvant chemotherapy and surgery) or Arm 2 (neoantigen vaccine following neoadjuvant chemotherapy in the window prior to surgery). Those who are ineligible for vaccine administration including those whose disease progresses or recurs during neoadjuvant chemo or who are otherwise unable to complete surgical resection but who had a personalized neoantigen vaccine manufactured, or significant progress has been made as determined by treating physician, are permitted to receive vaccine injections on study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05111353
Study type	Interventional
Source	Washington University School of Medicine
Contact	William E Gillanders, M.D.
Phone	314-747-0072
Email	gillandersw@wustl.edu
Status	Recruiting
Phase	Phase 1
Start date	December 15, 2022
Completion date	December 31, 2027

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