Anti-Tumor Immunity Induced by IRE of Unresectable Pancreatic Cancer

Status Completed

Clinical Trial Summary

This protocol will study the impact of Irreversible electroporation (IRE) on immune response in patients diagnosed with unresectable pancreatic cancers smaller than 5.0 cm. It will profile the immune response to IRE of unresectable pancreatic cancers. The intra-tumoral and systemic immune response to IRE will be determined and compared to pre-ablated pancreatic cancer specimens and historical control specimens.

Clinical Trial Description

Thirty patients with histologically confirmed locally advanced pancreatic adenocarcinoma (≤5.0cm) will undergo percutaneous irreversible electroporation of the tumor using CT and ultrasound guidance. Blood will be drawn for research before IRE. Blood and tissue samples will be used. After IRE, patients will be carefully monitored and systemic immune responses are registered. Follow-up will consist of frequent CT and MRI scanning, as well as serum CA19.9 tumor marker and quality of life questionnaires and overall survival (OS). The investigators hypothesize that IRE in the pancreas will induce good symptom palliation without causing severe complications as well as perfect systemic immune response. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02343835
Study type	Interventional
Source	Fuda Cancer Hospital, Guangzhou
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2015
Completion date	May 1, 2021

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