Pancreatic Cancer Clinical Trial
Official title:
Phase II Study of Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer
Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. Hydroxychloroquine may inactivate these pathways and results in the death of pancreatic cancer cells.
Every 4 weeks is considered one cycle. Participants will begin taking hydroxychloroquine
orally twice per day starting on Cycle 1 Day 1. They will need to return to the clinic every
two weeks for blood tests and to see the doctor or nurse practitioner.
Participants may remain on the study indefinitely as long as it is in their best interest to
do so. They will have CT scans every 8 weeks which will help determine if the cancer is
growing or staying the same.
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