Pancreatic Cancer Clinical Trial
Official title:
Developing Biomarkers in Pancreatic Cancer
RATIONALE: Studying samples of tissue in the laboratory from patients with cancer may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how patients will respond to treatment.
PURPOSE: This research study is studying biomarkers in patients with pancreatic cancer.
OBJECTIVES:
- To determine whether the cellular localization of BRCA1 can predict how patients with
pancreatic cancer will respond to cytotoxic agents (e.g., fluorouracil or gemcitabine
hydrochloride) or radiotherapy.
- To identify pre-treatment markers that can be used to correlate with clinical outcomes
of survival and recurrence.
- To determine if a method of extracting and identifying secreted cytokines and growth
factors from biopsy tissue can now be applied to the pancreatic cancer population.
OUTLINE: Tissue samples from biopsies performed during pancreatectomy are collected from the
Vanderbilt Ingram Cancer Center Human Tissue Acquisition Core for laboratory biomarker
studies. Proteins secreted by cancer cells and/or cancer-associated cells are studied by
extracting and identifying secreted cytokines and growth factors from biopsy tissue. The
integrity of the DNA repair pathway in pancreatic cancer is analyzed by Rad51 and
phosphorylated DNA-PK foci formation. Markers are correlated with clinical outcome.
Patients are followed for recurrence, relapse, and death from disease.
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Observational Model: Case-Only, Time Perspective: Prospective
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