Pancreatic Cancer Clinical Trial
Official title:
Phase II Study of SIRT and SERT With Chemotherapy in Patients With Recurrent /Metastatic Pancreatic Cancer
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to
the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in
chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving radiation
therapy in different ways and giving it together with chemotherapy may kill more tumor
cells.
PURPOSE: This phase II trial is studying the side effects and how well giving internal
radiation therapy and external radiation therapy together with fluorouracil works in
treating patients with newly diagnosed or recurrent pancreatic cancer and liver metastases
that cannot be removed by surgery.
OBJECTIVES:
Primary
- Determine tumor response in patients with unresectable, newly diagnosed or recurrent
pancreatic cancer and liver metastases treated with selective internal radiotherapy
with yttrium Y 90 microspheres, selective external radiotherapy with tomotherapy, and
fluoroucacil.
- Determine hepatic and systemic toxicity of this regimen in these patients.
Secondary
- Determine the efficacy of this regimen, in terms of time to progression and survival,
in these patients.
OUTLINE: Patients receive fluorouracil IV continuously on days 1-4. Patients undergo
selective internal radiotherapy with yttrium Y 90 microspheres on day 2 and selective
external radiotherapy with tomotherapy on day 3.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Treatment
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