Pancreatic Cancer Clinical Trial
Official title:
A Study of Gemcitabine, Cisplatin, and 5-Fluorouracil in the Treatment of Advanced Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating
adult patients who have stage III or stage IV pancreatic cancer that cannot be removed by
surgery.
OBJECTIVES: I. Determine the overall survival in patients with unresectable stage III or IV
pancreatic adenocarcinoma treated with gemcitabine, cisplatin, and fluorouracil. II.
Determine the resectability rate with curative intent in patients with unresectable stage
III pancreatic adenocarcinoma treated with this regimen. III. Assess the tolerability and
toxicity of this treatment regimen in this patient population. IV. Evaluate this regimen in
terms of response rate, response duration, and overall time to disease progression in these
patients. V. Evaluate the quality of life in these patients.
OUTLINE: Patients receive gemcitabine IV over 30 minutes on days 1, 8, and 15, followed by
cisplatin IV over 30 minutes on days 1 and 15. Patients receive fluorouracil as a continuous
infusion on days 1-15. Courses repeat every 28 days. Quality of life is assessed every 28
days.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
;
Primary Purpose: Treatment
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