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Pancreatic Cancer Stage IV clinical trials

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NCT ID: NCT04852367 Withdrawn - Clinical trials for Pancreatic Ductal Adenocarcinoma

PanDox: Targeted Doxorubicin in Pancreatic Tumours

PanDox
Start date: June 16, 2021
Phase: Phase 1
Study type: Interventional

This study will combine focused ultrasound to generate heat, and a heat-sensitive chemotherapy drug (ThermoDox®), delivered into the blood of participants with non-resectable pancreatic cancer. We will compare this to standard delivery of chemotherapy - the drug Doxorubicin given into the blood without the addition of ultrasound. We aim to determine whether the novel approach to delivering chemotherapy with heating the tumour by focused ultrasound can enhance the amount of drug delivered to pancreatic tumours. This will be measured by analysing a biopsy sample of treated tumour.