Pancreatic Adenocarcinoma Clinical Trial
Official title:
A Randomized Phase II Study of Perioperative mFOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel as Therapy for Resectable Pancreatic Adenocarcinoma
Verified date | October 2022 |
Source | Southwest Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This randomized phase II trial studies how well fluorouracil, irinotecan hydrochloride, and oxaliplatin (combination chemotherapy) works and compares to gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle formulation before surgery in treating patients with pancreatic cancer that can be removed by surgery. Drugs used in chemotherapy, such as fluorouracil, irinotecan hydrochloride, oxaliplatin, gemcitabine hydrochloride, and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective than gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle formulation before surgery in treating pancreatic cancer.
Status | Completed |
Enrollment | 147 |
Est. completion date | September 26, 2022 |
Est. primary completion date | May 31, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Patients must have histologically or cytologically proven pancreatic adenocarcinoma; histologies other than adenocarcinoma, or any mixed histologies, will NOT be eligible - Patients must have measurable disease in the pancreas; computed tomography (CT) scans or magnetic resonance imaging (MRIs) used to assess measurable disease must have been completed within 28 days prior to registration; all disease must be assessed and documented on the baseline tumor assessment form - Patients must have resectable primary tumor based on contrast-enhanced CT or MRI (CT or MRI without contrast as part of positron emission tomography [PET]/CT or PET/MRI is NOT acceptable; CT or MRI with contrast as part of PET/CT or PET/MRI is acceptable) of the chest, abdomen, and pelvis, where resectable is defined as: - No involvement of the celiac artery, common hepatic artery, and superior mesenteric artery (and, if present, replaced right hepatic artery) - No involvement, or < 180° interface between tumor and vessel wall, of the portal vein and/or superior mesenteric vein; and patent portal vein/splenic vein confluence - No evidence of metastatic disease - Note: for tumors of the body and tail of the pancreas, involvement of the splenic artery and vein of any degree is considered resectable disease - CT scans or MRIs used to assess disease at baseline must be submitted for central review - Patients must have surgical consult to verify patient is a surgical candidate within 21 days prior to registration - Patients must not have received prior surgery, radiation therapy, chemotherapy, targeted therapy, or any investigational therapy for pancreatic cancer - Patients must have a Zubrod performance status of 0-1 - Absolute neutrophil count (ANC) >= 1,500/mcL - Platelets >= 100,000/mcL - Hemoglobin >= 9 g/dL - Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN - Serum albumin >= 3 g/dL - Serum creatinine =< IULN within 14 days prior to registration - Patients with uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements will NOT be eligible - No prior malignancy is allowed except for adequately treated basal (or squamous cell) skin cancer, in situ cervical cancer, in situ breast (ductal or lobular) cancer, or other cancer for which the patient has been disease and treatment-free for two years - Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method for up to 3 months after the final administered dose of chemotherapy; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures, he/she is responsible for beginning contraceptive measures - Sites must seek additional patient consent for the future use of specimens - Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines - As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system |
Country | Name | City | State |
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United States | Hawaii Oncology Inc-Pali Momi | 'Aiea | Hawaii |
United States | Pali Momi Medical Center | 'Aiea | Hawaii |
United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
United States | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington |
United States | Abington Memorial Hospital | Abington | Pennsylvania |
United States | Hickman Cancer Center | Adrian | Michigan |
United States | Cleveland Clinic Akron General | Akron | Ohio |
United States | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico |
United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
United States | Mary Greeley Medical Center | Ames | Iowa |
United States | McFarland Clinic PC - Ames | Ames | Iowa |
United States | Cancer Care Center at Island Hospital | Anacortes | Washington |
United States | Kaiser Permanente-Anaheim | Anaheim | California |
United States | Alaska Breast Care and Surgery LLC | Anchorage | Alaska |
United States | Alaska Oncology and Hematology LLC | Anchorage | Alaska |
United States | Alaska Regional Hospital | Anchorage | Alaska |
United States | Alaska Women's Cancer Care | Anchorage | Alaska |
United States | Anchorage Associates in Radiation Medicine | Anchorage | Alaska |
United States | Anchorage Oncology Centre | Anchorage | Alaska |
United States | Anchorage Radiation Therapy Center | Anchorage | Alaska |
United States | Katmai Oncology Group | Anchorage | Alaska |
United States | Providence Alaska Medical Center | Anchorage | Alaska |
United States | Saint Joseph Mercy Hospital | Ann Arbor | Michigan |
United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
United States | Randolph Hospital | Asheboro | North Carolina |
United States | AdventHealth Infusion Center Asheville | Asheville | North Carolina |
United States | Duluth Clinic Ashland | Ashland | Wisconsin |
United States | Emory Saint Joseph's Hospital | Atlanta | Georgia |
United States | Emory University Hospital Midtown | Atlanta | Georgia |
United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
United States | Grady Health System | Atlanta | Georgia |
United States | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York |
United States | Sutter Auburn Faith Hospital | Auburn | California |
United States | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California |
United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
United States | Rush - Copley Medical Center | Aurora | Illinois |
United States | University of Colorado Hospital | Aurora | Colorado |
United States | Texas Oncology - Central Austin Cancer Center | Austin | Texas |
United States | Texas Oncology - South Austin Cancer Center | Austin | Texas |
United States | Texas Oncology-Austin Midtown | Austin | Texas |
United States | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon |
United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
United States | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri |
United States | Flaget Memorial Hospital | Bardstown | Kentucky |
United States | Medical Center of Baton Rouge | Baton Rouge | Louisiana |
United States | Ochsner Health Center-Summa | Baton Rouge | Louisiana |
United States | Bronson Battle Creek | Battle Creek | Michigan |
United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
United States | Indu and Raj Soin Medical Center | Beavercreek | Ohio |
United States | Swedish Cancer Institute-Eastside Oncology Hematology | Bellevue | Washington |
United States | Kaiser Permanente-Bellflower | Bellflower | California |
United States | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington |
United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
United States | Saint Charles Health System | Bend | Oregon |
United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
United States | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania |
United States | Constantinou, Costas L MD (UIA Investigator) | Bettendorf | Iowa |
United States | Billings Clinic Cancer Center | Billings | Montana |
United States | Saint Vincent Healthcare | Billings | Montana |
United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
United States | Saint Joseph Medical Center | Bloomington | Illinois |
United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
United States | Saint Luke's Mountain States Tumor Institute | Boise | Idaho |
United States | Central Care Cancer Center - Bolivar | Bolivar | Missouri |
United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
United States | McFarland Clinic PC-Boone | Boone | Iowa |
United States | Boston Medical Center | Boston | Massachusetts |
United States | Bozeman Deaconess Hospital | Bozeman | Montana |
United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
United States | Cox Cancer Center Branson | Branson | Missouri |
United States | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington |
United States | Harrison Medical Center | Bremerton | Washington |
United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
United States | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan |
United States | Saint Joseph Mercy Brighton | Brighton | Michigan |
United States | Wellmont Bristol Regional Medical Center | Bristol | Tennessee |
United States | Wellmont Medical Associates Oncology and Hematology-Bristol | Bristol | Tennessee |
United States | Wellmont Medical Associates-Bristol | Bristol | Virginia |
United States | Montefiore Medical Center - Moses Campus | Bronx | New York |
United States | Montefiore Medical Center-Einstein Campus | Bronx | New York |
United States | Montefiore Medical Center-Weiler Hospital | Bronx | New York |
United States | Saint Joseph Regional Cancer Center | Bryan | Texas |
United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
United States | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California |
United States | Highline Medical Center-Main Campus | Burien | Washington |
United States | Mills-Peninsula Medical Center | Burlingame | California |
United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
United States | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina |
United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
United States | University of Vermont and State Agricultural College | Burlington | Vermont |
United States | University of Vermont Medical Center | Burlington | Vermont |
United States | Fairview Ridges Hospital | Burnsville | Minnesota |
United States | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana |
United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
United States | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California |
United States | IHA Hematology Oncology Consultants-Canton | Canton | Michigan |
United States | Illinois CancerCare-Canton | Canton | Illinois |
United States | Saint Joseph Mercy Canton | Canton | Michigan |
United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
United States | Southeast Cancer Center | Cape Girardeau | Missouri |
United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
United States | Caro Cancer Center | Caro | Michigan |
United States | SIH Cancer Institute | Carterville | Illinois |
United States | Illinois CancerCare-Carthage | Carthage | Illinois |
United States | Eden Hospital Medical Center | Castro Valley | California |
United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
United States | Miami Valley Hospital South | Centerville | Ohio |
United States | Centralia Oncology Clinic | Centralia | Illinois |
United States | Providence Regional Cancer System-Centralia | Centralia | Washington |
United States | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania |
United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
United States | Geauga Hospital | Chardon | Ohio |
United States | Bon Secours Saint Francis Hospital | Charleston | South Carolina |
United States | Charleston Oncology - Roper | Charleston | South Carolina |
United States | Charleston Oncology - Saint Francis | Charleston | South Carolina |
United States | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina |
United States | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina |
United States | Medical University of South Carolina | Charleston | South Carolina |
United States | Roper Hospital | Charleston | South Carolina |
United States | West Virginia University Charleston Division | Charleston | West Virginia |
United States | Memorial Hospital | Chattanooga | Tennessee |
United States | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan |
United States | Saint Joseph Mercy Chelsea | Chelsea | Michigan |
United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
United States | Adena Regional Medical Center | Chillicothe | Ohio |
United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
United States | Bethesda North Hospital | Cincinnati | Ohio |
United States | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio |
United States | Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio |
United States | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio |
United States | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio |
United States | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio |
United States | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio |
United States | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio |
United States | TriHealth Cancer Institute-Westside | Cincinnati | Ohio |
United States | University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio |
United States | Clackamas Radiation Oncology Center | Clackamas | Oregon |
United States | Providence Oncology and Hematology Care Southeast | Clackamas | Oregon |
United States | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan |
United States | Newland Medical Associates-Clarkston | Clarkston | Michigan |
United States | Case Western Reserve University | Cleveland | Ohio |
United States | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio |
United States | Cleveland Clinic Foundation | Cleveland | Ohio |
United States | MetroHealth Medical Center | Cleveland | Ohio |
United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
United States | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa |
United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
United States | Big Horn Basin Cancer Center | Cody | Wyoming |
United States | Billings Clinic-Cody | Cody | Wyoming |
United States | Kootenai Medical Center | Coeur d'Alene | Idaho |
United States | Coffeyville Regional Medical Center | Coffeyville | Kansas |
United States | Integrity Oncology PLLC-Collierville | Collierville | Tennessee |
United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
United States | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado |
United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
United States | University of Missouri - Ellis Fischel | Columbia | Missouri |
United States | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi |
United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
United States | Doctors Hospital | Columbus | Ohio |
United States | Grant Medical Center | Columbus | Ohio |
United States | Mount Carmel East Hospital | Columbus | Ohio |
United States | Mount Carmel Health Center West | Columbus | Ohio |
United States | Riverside Methodist Hospital | Columbus | Ohio |
United States | The Mark H Zangmeister Center | Columbus | Ohio |
United States | Mercy Hospital | Coon Rapids | Minnesota |
United States | Bay Area Hospital | Coos Bay | Oregon |
United States | UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs | Florida |
United States | Baptist Health Corbin | Corbin | Kentucky |
United States | Commonwealth Cancer Center-Corbin | Corbin | Kentucky |
United States | Alegent Health Mercy Hospital | Council Bluffs | Iowa |
United States | Greater Regional Medical Center | Creston | Iowa |
United States | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky |
United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
United States | Parkland Memorial Hospital | Dallas | Texas |
United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
United States | Carle on Vermilion | Danville | Illinois |
United States | Geisinger Medical Center | Danville | Pennsylvania |
United States | Sutter Davis Hospital | Davis | California |
United States | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio |
United States | Good Samaritan Hospital - Dayton | Dayton | Ohio |
United States | Miami Valley Hospital | Dayton | Ohio |
United States | Miami Valley Hospital North | Dayton | Ohio |
United States | Beaumont Hospital - Dearborn | Dearborn | Michigan |
United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
United States | Decatur Memorial Hospital | Decatur | Illinois |
United States | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida |
United States | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois |
United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
United States | Delaware Radiation Oncology | Delaware | Ohio |
United States | Grady Memorial Hospital | Delaware | Ohio |
United States | Porter Adventist Hospital | Denver | Colorado |
United States | Broadlawns Medical Center | Des Moines | Iowa |
United States | Iowa Lutheran Hospital | Des Moines | Iowa |
United States | Iowa Methodist Medical Center | Des Moines | Iowa |
United States | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa |
United States | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa |
United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
United States | Ascension Saint John Hospital | Detroit | Michigan |
United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
United States | Epic Care-Dublin | Dublin | California |
United States | Essentia Health Cancer Center | Duluth | Minnesota |
United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
United States | Miller-Dwan Hospital | Duluth | Minnesota |
United States | Mercy Medical Center | Durango | Colorado |
United States | Southwest Oncology PC | Durango | Colorado |
United States | Duke University Medical Center | Durham | North Carolina |
United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
United States | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York |
United States | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin |
United States | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin |
United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
United States | Fairview-Southdale Hospital | Edina | Minnesota |
United States | Swedish Cancer Institute-Edmonds | Edmonds | Washington |
United States | Carle Physician Group-Effingham | Effingham | Illinois |
United States | Crossroads Cancer Center | Effingham | Illinois |
United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
United States | Hardin Memorial Hospital | Elizabethtown | Kentucky |
United States | Mercy Cancer Center-Elyria | Elyria | Ohio |
United States | Bay Area Breast Surgeons Inc | Emeryville | California |
United States | Epic Care Partners in Cancer Care | Emeryville | California |
United States | Walter Knox Memorial Hospital | Emmett | Idaho |
United States | Englewood Hospital and Medical Center | Englewood | New Jersey |
United States | Saint Elizabeth Hospital | Enumclaw | Washington |
United States | Illinois CancerCare-Eureka | Eureka | Illinois |
United States | Deaconess Clinic Downtown | Evansville | Indiana |
United States | Providence Regional Cancer Partnership | Everett | Washington |
United States | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio |
United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
United States | Sanford Broadway Medical Center | Fargo | North Dakota |
United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
United States | Farmington Health Center | Farmington | Utah |
United States | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan |
United States | Weisberg Cancer Treatment Center | Farmington Hills | Michigan |
United States | Saint Francis Hospital | Federal Way | Washington |
United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
United States | Armes Family Cancer Center | Findlay | Ohio |
United States | Blanchard Valley Hospital | Findlay | Ohio |
United States | Orion Cancer Care | Findlay | Ohio |
United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
United States | Genesee Hematology Oncology PC | Flint | Michigan |
United States | Genesys Hurley Cancer Institute | Flint | Michigan |
United States | Hurley Medical Center | Flint | Michigan |
United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
United States | Kaiser Permanente-Fontana | Fontana | California |
United States | Poudre Valley Hospital | Fort Collins | Colorado |
United States | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa |
United States | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida |
United States | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas |
United States | Parkview Hospital Randallia | Fort Wayne | Indiana |
United States | Radiation Oncology Associates PC | Fort Wayne | Indiana |
United States | UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas |
United States | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio |
United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
United States | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee |
United States | Frederick Memorial Hospital | Frederick | Maryland |
United States | Kaiser Permanente-Fremont | Fremont | California |
United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
United States | Kaiser Permanente-Fresno | Fresno | California |
United States | Unity Hospital | Fridley | Minnesota |
United States | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho |
United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
United States | Central Care Cancer Center - Garden City | Garden City | Kansas |
United States | Saint Catherine Hospital | Garden City | Kansas |
United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
United States | Glens Falls Hospital | Glens Falls | New York |
United States | Mountain Blue Cancer Care Center | Golden | Colorado |
United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
United States | CHI Health Saint Francis | Grand Island | Nebraska |
United States | Grand Valley Oncology | Grand Junction | Colorado |
United States | Mercy Health Saint Mary's | Grand Rapids | Michigan |
United States | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan |
United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
United States | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas |
United States | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana |
United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
United States | Bellin Memorial Hospital | Green Bay | Wisconsin |
United States | Cone Health Cancer Center | Greensboro | North Carolina |
United States | Dayton Physicians LLC-Wayne | Greenville | Ohio |
United States | Greenville Health System Cancer Institute-Andrews | Greenville | South Carolina |
United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
United States | Saint Francis Cancer Center | Greenville | South Carolina |
United States | Saint Francis Hospital | Greenville | South Carolina |
United States | Wayne Hospital | Greenville | Ohio |
United States | Self Regional Healthcare | Greenwood | South Carolina |
United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
United States | Baptist Cancer Center-Grenada | Grenada | Mississippi |
United States | Legacy Mount Hood Medical Center | Gresham | Oregon |
United States | William Beaumont Hospital-Grosse Point | Grosse Pointe | Michigan |
United States | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan |
United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
United States | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan |
United States | Kaiser Permanente - Harbor City | Harbor City | California |
United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
United States | Hattiesburg Clinic - Hematology/Oncology Clinic | Hattiesburg | Mississippi |
United States | Hays Medical Center | Hays | Kansas |
United States | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania |
United States | Saint Peter's Community Hospital | Helena | Montana |
United States | AdventHealth Hendersonville | Hendersonville | North Carolina |
United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
United States | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee |
United States | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida |
United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
United States | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii |
United States | Hawaii Oncology Inc-Kuakini | Honolulu | Hawaii |
United States | Hawaii Oncology Inc-POB I | Honolulu | Hawaii |
United States | Island Urology | Honolulu | Hawaii |
United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
United States | Kuakini Medical Center | Honolulu | Hawaii |
United States | Queen's Medical Center | Honolulu | Hawaii |
United States | Straub Clinic and Hospital | Honolulu | Hawaii |
United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
United States | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas |
United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
United States | Ben Taub General Hospital | Houston | Texas |
United States | Cancer Center of Kansas-Independence | Independence | Kansas |
United States | Centerpoint Medical Center LLC | Independence | Missouri |
United States | Cleveland Clinic Cancer Center Independence | Independence | Ohio |
United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
United States | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana |
United States | Kaiser Permanente-Irvine | Irvine | California |
United States | Swedish Cancer Institute-Issaquah | Issaquah | Washington |
United States | Allegiance Health | Jackson | Michigan |
United States | Onslow Memorial Hospital | Jacksonville | North Carolina |
United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
United States | McFarland Clinic PC-Jefferson | Jefferson | Iowa |
United States | Capital Region Southwest Campus | Jefferson City | Missouri |
United States | Wellmont Medical Associates Oncology and Hematology-Johnson City | Johnson City | Tennessee |
United States | Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas |
United States | Freeman Health System | Joplin | Missouri |
United States | Mercy Hospital Joplin | Joplin | Missouri |
United States | Borgess Medical Center | Kalamazoo | Michigan |
United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
United States | West Michigan Cancer Center | Kalamazoo | Michigan |
United States | Kalispell Regional Medical Center | Kalispell | Montana |
United States | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri |
United States | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri |
United States | Research Medical Center | Kansas City | Missouri |
United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
United States | The University of Kansas Cancer Center-North | Kansas City | Missouri |
United States | The University of Kansas Cancer Center-South | Kansas City | Missouri |
United States | Truman Medical Center | Kansas City | Missouri |
United States | University of Kansas Cancer Center | Kansas City | Kansas |
United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
United States | CHI Health Good Samaritan | Kearney | Nebraska |
United States | Heartland Hematology and Oncology | Kearney | Nebraska |
United States | Ochsner Medical Center Kenner | Kenner | Louisiana |
United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
United States | First Dayton Cancer Care | Kettering | Ohio |
United States | Greater Dayton Cancer Center | Kettering | Ohio |
United States | Kettering Medical Center | Kettering | Ohio |
United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
United States | Cancer Center of Kansas-Kingman | Kingman | Kansas |
United States | Regional Cancer Center at Indian Path Community Hospital | Kingsport | Tennessee |
United States | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee |
United States | Vidant Oncology-Kinston | Kinston | North Carolina |
United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
United States | UC San Diego Moores Cancer Center | La Jolla | California |
United States | Providence Regional Cancer System-Lacey | Lacey | Washington |
United States | The Watson Clinic | Lakeland | Florida |
United States | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado |
United States | Saint Anthony Hospital | Lakewood | Colorado |
United States | Saint Clare Hospital | Lakewood | Washington |
United States | Fairfield Medical Center | Lancaster | Ohio |
United States | Sparrow Hospital | Lansing | Michigan |
United States | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico |
United States | Lawrence Memorial Hospital | Lawrence | Kansas |
United States | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma |
United States | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire |
United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
United States | The University of Kansas Cancer Center-Lee's Summit | Lee's Summit | Missouri |
United States | Cape Fear Cancer Specialists-Leland | Leland | North Carolina |
United States | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas |
United States | Minimally Invasive Surgery Hospital | Lenexa | Kansas |
United States | Beebe Medical Center | Lewes | Delaware |
United States | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania |
United States | Lewistown Hospital | Lewistown | Pennsylvania |
United States | Baptist Health Lexington | Lexington | Kentucky |
United States | Saint Joseph Hospital East | Lexington | Kentucky |
United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
United States | Liberty Radiation Oncology Center | Liberty | Missouri |
United States | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii |
United States | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska |
United States | Littleton Adventist Hospital | Littleton | Colorado |
United States | Hope Cancer Clinic | Livonia | Michigan |
United States | Saint Mary Mercy Hospital | Livonia | Michigan |
United States | Saint Joseph London | London | Kentucky |
United States | Longmont United Hospital | Longmont | Colorado |
United States | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado |
United States | PeaceHealth Saint John Medical Center | Longview | Washington |
United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
United States | Kaiser Permanente-Cadillac | Los Angeles | California |
United States | Los Angeles County-USC Medical Center | Los Angeles | California |
United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
United States | Baptist Health Louisville | Louisville | Kentucky |
United States | Jewish Hospital | Louisville | Kentucky |
United States | Jewish Hospital Medical Center Northeast | Louisville | Kentucky |
United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
United States | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky |
United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
United States | Illinois CancerCare-Macomb | Macomb | Illinois |
United States | Michigan Breast Specialists-Macomb Township | Macomb | Michigan |
United States | University of Wisconsin Hospital and Clinics | Madison | Wisconsin |
United States | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky |
United States | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire |
United States | Cancer Center of Kansas-Manhattan | Manhattan | Kansas |
United States | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio |
United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
United States | Fairview Maple Grove Medical Center | Maple Grove | Minnesota |
United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
United States | Marietta Memorial Hospital | Marietta | Ohio |
United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
United States | Bay Area Medical Center | Marinette | Wisconsin |
United States | OhioHealth Marion General Hospital | Marion | Ohio |
United States | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan |
United States | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa |
United States | Marshfield Medical Center | Marshfield | Wisconsin |
United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
United States | Contra Costa Regional Medical Center | Martinez | California |
United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
United States | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio |
United States | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio |
United States | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio |
United States | UH Seidman Cancer Center at Landerbrook Health Center | Mayfield Heights | Ohio |
United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
United States | Cone Heath Cancer Center at Mebane | Mebane | North Carolina |
United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
United States | Riddle Memorial Hospital | Media | Pennsylvania |
United States | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee |
United States | Baptist Memorial Hospital for Women | Memphis | Tennessee |
United States | Family Cancer Center-Memphis | Memphis | Tennessee |
United States | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio |
United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
United States | Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho |
United States | Jackson Memorial Hospital-Holtz Children's Hospital | Miami | Florida |
United States | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida |
United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
United States | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana |
United States | Woodland Cancer Care Center | Michigan City | Indiana |
United States | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio |
United States | Dayton Physicians LLC-Signal Point | Middletown | Ohio |
United States | Orange Regional Medical Center | Middletown | New York |
United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
United States | NYU Winthrop Hospital | Mineola | New York |
United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
United States | Health Partners Inc | Minneapolis | Minnesota |
United States | Hennepin County Medical Center | Minneapolis | Minnesota |
United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
United States | Community Medical Hospital | Missoula | Montana |
United States | Saint Patrick Hospital - Community Hospital | Missoula | Montana |
United States | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama |
United States | Kaiser Permanente-Modesto | Modesto | California |
United States | Memorial Medical Center | Modesto | California |
United States | Garneau, Stewart C MD (UIA Investigator) | Moline | Illinois |
United States | Spector, David MD (UIA Investigator) | Moline | Illinois |
United States | Trinity Medical Center | Moline | Illinois |
United States | Monroe Cancer Center | Monroe | Michigan |
United States | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan |
United States | University Health-Conway | Monroe | Louisiana |
United States | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina |
United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
United States | Knox Community Hospital | Mount Vernon | Ohio |
United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
United States | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California |
United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
United States | Mercy Health Mercy Campus | Muskegon | Michigan |
United States | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho |
United States | Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho |
United States | Norris Cotton Cancer Center-Nashua | Nashua | New Hampshire |
United States | Meharry Medical College | Nashville | Tennessee |
United States | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee |
United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
United States | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi |
United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
United States | University Medical Center New Orleans | New Orleans | Louisiana |
United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
United States | New Ulm Medical Center | New Ulm | Minnesota |
United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
United States | Christiana Gynecologic Oncology LLC | Newark | Delaware |
United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
United States | Helen F Graham Cancer Center | Newark | Delaware |
United States | Licking Memorial Hospital | Newark | Ohio |
United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
United States | Newark Radiation Oncology | Newark | Ohio |
United States | Providence Newberg Medical Center | Newberg | Oregon |
United States | Chancellor Center for Oncology | Newburgh | Indiana |
United States | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California |
United States | Cancer Center of Kansas - Newton | Newton | Kansas |
United States | Lakeland Hospital Niles | Niles | Michigan |
United States | Southwest VA Regional Cancer Center | Norton | Virginia |
United States | Sutter Cancer Research Consortium | Novato | California |
United States | Alta Bates Summit Medical Center - Summit Campus | Oakland | California |
United States | Bay Area Tumor Institute | Oakland | California |
United States | Kaiser Permanente-Oakland | Oakland | California |
United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
United States | Olathe Medical Center | Olathe | Kansas |
United States | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska |
United States | Alegent Health Immanuel Medical Center | Omaha | Nebraska |
United States | Alegent Health Lakeside Hospital | Omaha | Nebraska |
United States | Creighton University Medical Center | Omaha | Nebraska |
United States | Hematology and Oncology Consultants PC | Omaha | Nebraska |
United States | Nebraska Methodist Hospital | Omaha | Nebraska |
United States | University of Nebraska Medical Center | Omaha | Nebraska |
United States | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon |
United States | Memorial GYN Plus | Ooltewah | Tennessee |
United States | Saint Joseph Hospital - Orange | Orange | California |
United States | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California |
United States | Saint Charles Hospital | Oregon | Ohio |
United States | Providence Willamette Falls Medical Center | Oregon City | Oregon |
United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
United States | Radiation Oncology of Northern Illinois | Ottawa | Illinois |
United States | Menorah Medical Center | Overland Park | Kansas |
United States | Saint Luke's South Hospital | Overland Park | Kansas |
United States | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas |
United States | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi |
United States | Baptist Health Paducah | Paducah | Kentucky |
United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
United States | Kaiser Permanente - Panorama City | Panorama City | California |
United States | Paoli Memorial Hospital | Paoli | Pennsylvania |
United States | Midlands Community Hospital | Papillion | Nebraska |
United States | Parker Adventist Hospital | Parker | Colorado |
United States | Rocky Mountain Cancer Centers-Parker | Parker | Colorado |
United States | University Hospitals Parma Medical Center | Parma | Ohio |
United States | Cancer Center of Kansas - Parsons | Parsons | Kansas |
United States | Keck Medical Center of USC Pasadena | Pasadena | California |
United States | Illinois CancerCare-Pekin | Pekin | Illinois |
United States | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois |
United States | Illinois CancerCare-Peoria | Peoria | Illinois |
United States | Methodist Medical Center of Illinois | Peoria | Illinois |
United States | OSF Saint Francis Medical Center | Peoria | Illinois |
United States | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois |
United States | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio |
United States | Illinois CancerCare-Peru | Peru | Illinois |
United States | Valley Radiation Oncology | Peru | Illinois |
United States | Fox Chase Cancer Center | Philadelphia | Pennsylvania |
United States | Temple University Hospital | Philadelphia | Pennsylvania |
United States | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania |
United States | University of Arizona Cancer Center at Saint Joseph's | Phoenix | Arizona |
United States | Via Christi Hospital-Pittsburg | Pittsburg | Kansas |
United States | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida |
United States | 21st Century Oncology-Pontiac | Pontiac | Michigan |
United States | Hope Cancer Center | Pontiac | Michigan |
United States | Newland Medical Associates-Pontiac | Pontiac | Michigan |
United States | Saint Joseph Mercy Oakland | Pontiac | Michigan |
United States | Kaiser Permanente Northwest | Portland | Oregon |
United States | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon |
United States | Providence Portland Medical Center | Portland | Oregon |
United States | Providence Saint Vincent Medical Center | Portland | Oregon |
United States | Southern Ohio Medical Center | Portsmouth | Ohio |
United States | Kootenai Cancer Center | Post Falls | Idaho |
United States | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania |
United States | Vassar Brothers Medical Center | Poughkeepsie | New York |
United States | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington |
United States | Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas |
United States | Cancer Center of Kansas - Pratt | Pratt | Kansas |
United States | Illinois CancerCare-Princeton | Princeton | Illinois |
United States | Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado |
United States | Saint Mary Corwin Medical Center | Pueblo | Colorado |
United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
United States | Kaiser Permanente-Redwood City | Redwood City | California |
United States | Spectrum Health Reed City Hospital | Reed City | Michigan |
United States | Beebe Health Campus | Rehoboth Beach | Delaware |
United States | Annie Penn Memorial Hospital | Reidsville | North Carolina |
United States | Lakeview Medical Center-Marshfield Clinic | Rice Lake | Wisconsin |
United States | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin |
United States | Bon Secours Saint Mary's Hospital | Richmond | Virginia |
United States | Kaiser Permanente-Richmond | Richmond | California |
United States | Reid Health | Richmond | Indiana |
United States | Kaiser Permanente-Riverside | Riverside | California |
United States | North Memorial Medical Health Center | Robbinsdale | Minnesota |
United States | Mayo Clinic | Rochester | Minnesota |
United States | University of Rochester | Rochester | New York |
United States | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan |
United States | Penobscot Bay Medical Center | Rockport | Maine |
United States | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri |
United States | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri |
United States | Kaiser Permanente-Roseville | Roseville | California |
United States | Michigan Cancer Specialists | Roseville | Michigan |
United States | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California |
United States | Sutter Roseville Medical Center | Roseville | California |
United States | Texas Oncology - Round Rock Cancer Center | Round Rock | Texas |
United States | Cancer Care Associates PC | Royal Oak | Michigan |
United States | Comprehensive Medical Center PLLC | Royal Oak | Michigan |
United States | Hematology Oncology Consultants PC | Royal Oak | Michigan |
United States | Oakland Colon and Rectal Association | Royal Oak | Michigan |
United States | Oakland Medical Group | Royal Oak | Michigan |
United States | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan |
United States | Kaiser Permanente - Sacramento | Sacramento | California |
United States | Kaiser Permanente-South Sacramento | Sacramento | California |
United States | Sutter Medical Center Sacramento | Sacramento | California |
United States | Ascension Saint Mary's Hospital | Saginaw | Michigan |
United States | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan |
United States | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont |
United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
United States | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan |
United States | Marie Yeager Cancer Center | Saint Joseph | Michigan |
United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
United States | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri |
United States | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri |
United States | Siteman Cancer Center-South County | Saint Louis | Missouri |
United States | Washington University School of Medicine | Saint Louis | Missouri |
United States | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota |
United States | Regions Hospital | Saint Paul | Minnesota |
United States | United Hospital | Saint Paul | Minnesota |
United States | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri |
United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
United States | Salem Hospital | Salem | Oregon |
United States | Cancer Center of Kansas - Salina | Salina | Kansas |
United States | Salina Regional Health Center | Salina | Kansas |
United States | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah |
United States | Cancer Therapy and Research Center at The UT Health Science Center at San Antonio | San Antonio | Texas |
United States | University Hospital | San Antonio | Texas |
United States | University of Texas Health Science Center at San Antonio | San Antonio | Texas |
United States | Kaiser Permanente-San Diego Mission | San Diego | California |
United States | Kaiser Permanente-San Diego Zion | San Diego | California |
United States | University of California San Diego | San Diego | California |
United States | California Pacific Medical Center-Pacific Campus | San Francisco | California |
United States | Kaiser Permanente-San Francisco | San Francisco | California |
United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
United States | Kaiser Permanente San Leandro | San Leandro | California |
United States | Kaiser Permanente-San Marcos | San Marcos | California |
United States | Kaiser Permanente-San Rafael | San Rafael | California |
United States | Kaiser San Rafael-Gallinas | San Rafael | California |
United States | Kootenai Cancer Clinic | Sandpoint | Idaho |
United States | North Coast Cancer Care | Sandusky | Ohio |
United States | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio |
United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
United States | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California |
United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
United States | Sutter Pacific Medical Foundation | Santa Rosa | California |
United States | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania |
United States | Community Medical Center | Scranton | Pennsylvania |
United States | Nanticoke Memorial Hospital | Seaford | Delaware |
United States | Kaiser Permanente Washington | Seattle | Washington |
United States | Minor and James Medical PLLC | Seattle | Washington |
United States | Pacific Gynecology Specialists | Seattle | Washington |
United States | Swedish Medical Center-Ballard Campus | Seattle | Washington |
United States | Swedish Medical Center-First Hill | Seattle | Washington |
United States | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania |
United States | Grand View Hospital | Sellersville | Pennsylvania |
United States | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina |
United States | Saint Francis Regional Medical Center | Shakopee | Minnesota |
United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
United States | Providence Regional Cancer System-Shelton | Shelton | Washington |
United States | Jewish Hospital Medical Center South | Shepherdsville | Kentucky |
United States | Welch Cancer Center | Sheridan | Wyoming |
United States | Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana |
United States | Dayton Physicians LLC-Wilson | Sidney | Ohio |
United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
United States | South Jordan Health Center | South Jordan | Utah |
United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
United States | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi |
United States | Prisma Health Cancer Institute - Spartanburg | Spartanburg | South Carolina |
United States | Rockwood Cancer Treatment Center-DHEC-Downtown | Spokane | Washington |
United States | Rockwood North Cancer Treatment Center | Spokane | Washington |
United States | Rockwood Clinic Cancer Treatment Center-Valley | Spokane Valley | Washington |
United States | Baystate Medical Center | Springfield | Massachusetts |
United States | Central Illinois Hematology Oncology Center | Springfield | Illinois |
United States | CoxHealth South Hospital | Springfield | Missouri |
United States | Memorial Medical Center | Springfield | Illinois |
United States | Mercy Hospital Springfield | Springfield | Missouri |
United States | Southern Illinois University School of Medicine | Springfield | Illinois |
United States | Springfield Clinic | Springfield | Illinois |
United States | Springfield Regional Cancer Center | Springfield | Ohio |
United States | Springfield Regional Medical Center | Springfield | Ohio |
United States | Geisinger Medical Group | State College | Pennsylvania |
United States | Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan |
United States | Mitchell Folbe MD PC | Sterling Heights | Michigan |
United States | Premier Hematology Oncology Care | Sterling Heights | Michigan |
United States | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin |
United States | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin |
United States | Lakeview Hospital | Stillwater | Minnesota |
United States | Kaiser Permanente-Stockton | Stockton | California |
United States | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio |
United States | Missouri Baptist Sullivan Hospital | Sullivan | Missouri |
United States | Aurora Medical Center in Summit | Summit | Wisconsin |
United States | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California |
United States | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri |
United States | Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois |
United States | Southwest Illinois Health Services LLP | Swansea | Illinois |
United States | ProMedica Flower Hospital | Sylvania | Ohio |
United States | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York |
United States | State University of New York Upstate Medical University | Syracuse | New York |
United States | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington |
United States | Madigan Army Medical Center | Tacoma | Washington |
United States | Northwest Medical Specialties PLLC | Tacoma | Washington |
United States | Ascension Saint Joseph Hospital | Tawas City | Michigan |
United States | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado |
United States | Mercy Saint Anne Hospital | Toledo | Ohio |
United States | The Toledo Hospital/Toledo Children's Hospital | Toledo | Ohio |
United States | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio |
United States | Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas |
United States | Munson Medical Center | Traverse City | Michigan |
United States | Claudia BR Herke MD PC | Troy | Michigan |
United States | Dayton Physicians LLC-Upper Valley | Troy | Ohio |
United States | Hematology Oncology Consultants PC-Troy | Troy | Michigan |
United States | Michigan Institute of Urology-Town Center | Troy | Michigan |
United States | Upper Valley Medical Center | Troy | Ohio |
United States | William Beaumont Hospital - Troy | Troy | Michigan |
United States | Legacy Meridian Park Hospital | Tualatin | Oregon |
United States | Banner University Medical Center - Tucson | Tucson | Arizona |
United States | University of Arizona Cancer Center-North Campus | Tucson | Arizona |
United States | University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona |
United States | Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho |
United States | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin |
United States | Carle Cancer Center | Urbana | Illinois |
United States | The Carle Foundation Hospital | Urbana | Illinois |
United States | Kaiser Permanente Medical Center-Vacaville | Vacaville | California |
United States | Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California |
United States | Kaiser Permanente-Vallejo | Vallejo | California |
United States | Sutter Solano Medical Center/Cancer Center | Vallejo | California |
United States | Legacy Salmon Creek Hospital | Vancouver | Washington |
United States | PeaceHealth Southwest Medical Center | Vancouver | Washington |
United States | Essentia Health Virginia Clinic | Virginia | Minnesota |
United States | Ridgeview Medical Center | Waconia | Minnesota |
United States | University Hospitals Sharon Health Center | Wadsworth | Ohio |
United States | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington |
United States | Kaiser Permanente-Walnut Creek | Walnut Creek | California |
United States | Advanced Breast Care Center PLLC | Warren | Michigan |
United States | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan |
United States | Macomb Hematology Oncology PC | Warren | Michigan |
United States | Michigan Breast Specialists-Warren | Warren | Michigan |
United States | Saint John Macomb-Oakland Hospital | Warren | Michigan |
United States | South Pointe Hospital | Warrensville Heights | Ohio |
United States | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois |
United States | Mercy Hospital Washington | Washington | Missouri |
United States | Aurora Cancer Care-Waukesha | Waukesha | Wisconsin |
United States | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin |
United States | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin |
United States | Aspirus Regional Cancer Center | Wausau | Wisconsin |
United States | Marshfield Clinic-Wausau Center | Wausau | Wisconsin |
United States | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin |
United States | Cancer Center of Kansas - Wellington | Wellington | Kansas |
United States | Aurora West Allis Medical Center | West Allis | Wisconsin |
United States | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan |
United States | University Pointe | West Chester | Ohio |
United States | Mercy Medical Center-West Lakes | West Des Moines | Iowa |
United States | Methodist West Hospital | West Des Moines | Iowa |
United States | Veterans Affairs Connecticut Healthcare System-West Haven Campus | West Haven | Connecticut |
United States | Reading Hospital | West Reading | Pennsylvania |
United States | Saint Ann's Hospital | Westerville | Ohio |
United States | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio |
United States | UHHS-Westlake Medical Center | Westlake | Ohio |
United States | Ascension Saint Clare's Hospital | Weston | Wisconsin |
United States | Cleveland Clinic-Weston | Weston | Florida |
United States | Marshfield Clinic - Weston Center | Weston | Wisconsin |
United States | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas |
United States | Ascension Via Christi Hospitals Wichita | Wichita | Kansas |
United States | Associates In Womens Health | Wichita | Kansas |
United States | Cancer Center of Kansas - Wichita | Wichita | Kansas |
United States | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas |
United States | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania |
United States | Rice Memorial Hospital | Willmar | Minnesota |
United States | Cape Fear Cancer Specialists | Wilmington | North Carolina |
United States | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware |
United States | New Hanover Regional Medical Center/Zimmer Cancer Center | Wilmington | North Carolina |
United States | Winchester Hospital | Winchester | Massachusetts |
United States | Cancer Center of Kansas - Winfield | Winfield | Kansas |
United States | Southeast Clinical Oncology Research Consortium NCORP | Winston-Salem | North Carolina |
United States | Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin |
United States | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin |
United States | Inspira Medical Center Woodbury | Woodbury | New Jersey |
United States | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota |
United States | Kaiser Permanente-Woodland Hills | Woodland Hills | California |
United States | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio |
United States | Lankenau Medical Center | Wynnewood | Pennsylvania |
United States | Fairview Lakes Medical Center | Wyoming | Minnesota |
United States | Metro Health Hospital | Wyoming | Michigan |
United States | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington |
United States | Providence Regional Cancer System-Yelm | Yelm | Washington |
United States | Rush-Copley Healthcare Center | Yorkville | Illinois |
United States | Huron Gastroenterology PC | Ypsilanti | Michigan |
United States | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan |
United States | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio |
Lead Sponsor | Collaborator |
---|---|
Southwest Oncology Group | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall Survival (OS) | OS is the length of time between protocol registration and patient death | Up to 4 years for the estimates of median overall survival. Up to 2 years for Statistical Analysis 1 and 2, comparing the observed 2-year overall survival (OS) to the null hypothesis of 40%, in each arm. | |
Secondary | Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug | Only adverse events that are possibly, probably or definitely related to preoperative and postoperative chemotherapy are reported. | Duration of treatment and follow up until death or 4 years post registration. | |
Secondary | Number of Patients Going to Surgery for Resection After Preoperative Chemotherapy. | Up to 8 months post registration (and within 4 to 8 weeks after the last dose of Cycle 3 preoperative chemotherapy). | ||
Secondary | Number of Patients Achieving R0 Resection After Preoperative Chemotherapy. | R0 resection classification is defined as macroscopically complete tumor removal with negative microscopic surgical margins (bile duct, pancreatic parenchyma, and superior mesenteric artery margins). | Up to 8 months post registration (and within 4 to 8 weeks after the last dose of Cycle 3 preoperative chemotherapy). | |
Secondary | Number of Participants With a Response Following Preoperative Chemotherapy, Including Confirmed and Unconfirmed, Complete and Partial Response, Per RECIST 1.1. | Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI: Complete Response (CR), disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR. | Up to 6 months post registration (and within 2 to 4 weeks after the last dose of Cycle 3 preoperative chemotherapy.). | |
Secondary | Number of Participants With Complete Response, Moderate Response, Minimal Response, and Poor or No Response After Resection. | Pathologic response was evaluated after the patient had surgery, and was based on local pathology review of the resected surgical specimen, according to the following Tumor Regression Grade definitions:
0: Complete response - no residual tumor Moderate response - minimal residual cancer (single cells or small groups of cancer cells) Minimal response - residual cancer outgrown by fibrosis Poor or no response - no definite response identified (minimal or no tumor kill; extensive residual cancer) |
Up to 8 months post registration (and within 4 to 8 weeks after the last dose of Cycle 3 preoperative chemotherapy). | |
Secondary | Number of Participants With Loco-regional and Distant Recurrence After R0 or R1 Resection. | Loco-regional recurrence is defined as any evidence of new disease within the pancreatic tumor bed based on surveillance scans. The pancreatic tumor bed includes:
Superior mesenteric artery and vein lymph nodes Lymph nodes in porta hepatis (bile duct, portal vein, hepatic artery lymph nodes) Lymph nodes around left renal vein, inferior vena cava or aorta Celiac axis lymph nodes. Distant Recurrence is defined as any evidence of new disease outside the primary tumor bed (liver, lungs, etc.) based on surveillance scans. |
Up to 4 years | |
Secondary | Disease-free Survival From the Time of R0 or R1 Resection. | Disease-free survival (DFS) is calculated for patients who undergo surgical resection (R0/R1). DFS will be measured from the date of surgical resection to date of first documentation of recurrence (loco-regional or distant) or death due to any cause. Patients last known to be alive and free of disease will be censored at date of last contact. | Up to 4 years |
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