Gene Therapy for Painful Diabetic Neuropathy

Status Completed

Clinical Trial Summary

The purpose of this study is to assess the safety and tolerability of injecting VM202 in the leg muscle in patients with painful diabetic neuropathy (DPN). The study will also assess the potential of VM202 to reduce the pain associated with DPN.

Clinical Trial Description

Peripheral neuropathy is a serious complication of diabetes. This form of neuropathy carries a high risk of pain, trophic changes and autonomic dysfunction.

Currently, there are no approved drugs or interventional strategies known to halt or reverse the progression of DPN. Treatments target pain reduction, physical function improvement, reduction of psychological distress, and quality of life improvements.

There is currently no effective treatment for diabetic neuropathy, and good glycemic control is the only way to minimize the risk of occurrence. Clearly, it would be desirable to prevent, impede, or reverse the disrupting and often life-threatening manifestations of peripheral neuropathy by stimulating growth or regeneration of peripheral nerve axons. ;

Study Design

Related Conditions & MeSH terms

Diabetic Neuropathies
Pain
Painful Diabetic Neuropathy
Peripheral Nervous System Diseases

Clinical Trial Details

NCT number	NCT01002235
Study type	Interventional
Source	Helixmith Co., Ltd.
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	February 2010
Completion date	April 2012

View Details

See also
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Recruiting	`NCT05476276` - EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy	Phase 2
Unknown status	`NCT01125215` - Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy	Phase 2/Phase 3
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Completed	`NCT04005287` - A 24-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Peripheral Neuropathy	Phase 2
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Recruiting	`NCT03700528` - The Development of Contextual Cognitive Behavioural Approach to PDN	N/A
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Recruiting	`NCT04689971` - The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient	Phase 2/Phase 3
Recruiting	`NCT04689958` - The Benefits of Vitamin D 5000 IU as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient	Phase 2/Phase 3
Completed	`NCT03749642` - Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy	Phase 2
Not yet recruiting	`NCT04087941` - Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial	Phase 2
Terminated	`NCT01129960` - Eslicarbazepine Acetate as Therapy in Diabetic Neuropathic Pain	Phase 3
Terminated	`NCT01056315` - A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y	Phase 2
Completed	`NCT00980746` - Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Painful Diabetic Neuropathy	Phase 2
Completed	`NCT04786340` - A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral Neuropathy	Phase 2
Completed	`NCT03769675` - Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation	N/A
Completed	`NCT03755934` - Efficacy and Safety of MEDI7352 in Subjects With Painful Diabetic Neuropathy	Phase 2