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Paracetamol Effect on Prostaglandins and Blood Pressure — PIS-PaB  

Pain Clinical Trial

Official title:
Paracetamol Impact Study: Prostaglandin Synthesis and Blood Pressure Effects (PIS-PaB)

Clinical Trial Summary

This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06235320
Study type Observational
Source Charite University, Berlin, Germany
Contact Engi Algharably, PhD
Phone 030/ 450 525 221
Email engi.algharably@charite.de
Status Not yet recruiting
Phase
Start date March 1, 2024
Completion date March 1, 2026
View Details
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