Pericapsular Nerve Group Block vs Femoral Nerve Block for Perioperative Pain Management in Patients With Hip Fracture.

Pain Clinical Trial

Official title:

Pericapsular Nerve Group (PENG) Block Versus Femoral Never Block for Perioperative Pain Management in Patients With Hip Fracture: A Prospective Randomized Study.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05961436
• Other study ID #: FMBSUREC/06062023/Fakhry
• Status: Recruiting
• Phase: N/A
• Start date: June 30, 2023
• Est. completion date: December 31, 2023

Study information

• Verified date: July 2023
• Source: Beni-Suef University
• Contact: Dina M Fakhry, MD
• Phone: 201289998680
• Email: dina_fakhry_91[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this work is to compare between the use of PENG block and femoral nerve block for perioperative pain management in patients with hip fracture.

Description:

Hip fractures are common orthopaedic problem especially in elderly population which is associated with significant morbidity and mortality. Early surgical reduction and fixation is the preferred treatment in most patients. Significant pain, if inadequately controlled, can impair early rehabilitation and functional recovery and can reduce patient satisfaction after surgery . Combinations of systemic analgesics, intra-articular injection, and neuraxial and peripheral nerve blocks should be considered as the integral components of the perioperative pain management plan. Among these, intra-articular local anaesthetic injections have been shown to play a potential role in providing analgesia after hip arthroplasty. The risks of this procedure include hematoma, nerve damage, local anaesthetics toxicity, intravenous injection of local anesthetics and septic osteoarthritis, but their occurrence is very rare. Several peripheral nerve blocks, including fascia iliaca block, femoral block (FB), and some interfascial plane blocks such as quadratus lumborum block (QLB), have also been suggested to decrease postoperative pain and opioid use. Lumbar plexus block/psoas compartment block is a technically difficult deep block that requires greater skill and hence can be time consuming. The lumbar paravertebral region is highly vascular and non-compressible. Hence, patients on anti-coagulation are at high risk for bleeding complications. There is also high risk of unintentional neuraxial block or inadvertent intravascular injection with local anaesthetic systemic toxicity. Some nerve branches responsible for hip joint innervation may not be blocked by QLB, which should be taken into consideration while using these blocks for hip fracture. High-volume suprainguinal fascia iliaca block and traditional fascia iliaca block have also been reported to be associated with a significant incidence of muscle weakness and to predispose the patient to fall. The anterior hip capsule is innervated by the obturator nerve (ON), accessory obturator nerve (AON), and femoral nerve (FN) as reported by previous anatomic studies. The anterior capsule is the most richly innervated section of the joint, suggesting these nerves should be the main targets for hip analgesia. Femoral block (FB) does not block the AON or the articular branches of the ON. Also, femoral nerve block accompanied by decreasing the strength of quadriceps muscles. Pericapsular nerve group (PENG) block was described in 2018 and reported that it was successfully used for postoperative pain management in hip surgery. The PENG block is a technique that involves deposition of local anaesthetic in the musculofascial plane between the psoas muscle and the superior pubic ramus for the blockade of the articular branches of the FN, ON and AON that provide sensory innervation to the anterior hip capsule.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 31, 2023
• Est. primary completion date: December 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with a hip fracture.

• Aged 50 years and older.

Exclusion Criteria:

• Consent refusal.

• Allergy to local anaesthetics.

• Infection of the puncture site.

• Dementia or cognitive impairment.

Related Conditions & MeSH terms

• Hip Fractures
• Pain

Intervention

Procedure:
• PENG block
Using ultrasound-guided technique, a total of 20ml of 0.25 % bupivacaine will be injected after negative aspiration.
• FN block
Using ultrasound-guided technique, after negative aspiration, 20 mL of 0.25 % bupivacaine will be administered.

Locations

Country	Name	City	State
Egypt	Beni-Suef University hospital	Bani Suwayf	Beni-Suef

Sponsors (1)

Lead Sponsor	Collaborator
Beni-Suef University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quadriceps muscle strength in recovery.	Quadriceps muscle strength will be assessed using Oxford muscle strength grading with grouped scores of intact (5/5), reduced (1-4/5) and absent (0/5).; Muscle Grading Scores: 0 No detectable muscle contraction (visible or palpation); Detectable contraction (visible or palpation), but no movement achieved; Limb movement achieved, but unable to move against gravity; Limb movement against resistance of gravity; Limb movement against gravity and external resistance; Normal strength	24 hours of the procedure
Secondary	Visual analogue scale	before and 30 minutes after the block both at rest and during dynamic hip movement.; 0 means no pain 10 means the worst pain	24 hours of the procedure.