Pain Clinical Trial
Official title:
Pupillary Diameter Variations in Response to Tetanic Stimulations of Incremental Intensities in Patients Under Propofol-remifentanil TCI
In patients under standardized steady-state general anesthesia, 6 tetanic stimulations of incremental intensities were applied to the patients. Pupillary dilation in response to these stimulations was recorded.
The aim of the study was to investigate a possible correlation between the intensity of a
nociceptive stimulus and the magnitude of pupillary reflex dilation in patients anesthetized
with propofol and remifentanil target-controlled infusion.
Anesthetic protocol: 10 minutes of steady-state general anesthesia (before extubation during
a scheduled gynecological surgery) with remifentanil target concentration of 1 ng/ml, and
propofol target concentration adjusted to maintain bispectral index between 45 and 55.
Study period: 6 tetanic stimulations of incremental intensities were applied to the patients:
10, 20, 30, 40, 50, 60 milliamps Pupillary dilation in response to these stimulations was
recorded.
Then, propofol and remifentanil infusions were discontinued, and patients were extubated.
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