Pain Clinical Trial
Official title:
Efficacy of a Zinc-L-Carnosine -Based Mouth Rinse on Periodontal Tissues and Pain After Scaling and Root Planing - a Randomized Clinical Trial; a Randomized Controlled Trial
A clinical trial to assess the effect of a Zinc-L-Carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing
A randomized, double blind, 3 group parallel study with random allocation of 75 patients to
any of three groups; Zinc-L-Carnosine-based mouth rinse, Chlorhexidine mouth rinse and
placebo (water) control. Three days after professional oral hygiene, which aimed at the
normalization of the periodontal index, the primary (HI, VAS) and secondary (mSBI; FMPS; VMI;
SI) outcomes of the study are measured to obtain baseline information, and then scaling and
root planing are carried out.
The participants will be advised to follow their regular oral hygiene procedures (tooth
brushing) in addition to the allocated mouth rinse. They will be examined again for primary
and secondary outcomes at 7 and 21 days.
Clinical evaluation:
Clinical examination of each participant will be done by a single examiner using the
previously described VAS scale and a UNC periodontal probe (No. 5 explorer Hu-Friedy,
Chicago, Ill). In addition to these indices, each subject will be asked to report any adverse
events they have encountered during the experiment.
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