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Chronic Low Back Pain and Meditation

Pain Clinical Trial

Official title:
The Role of Endogenous Opioids in Mindfulness-based Chronic Pain Relief

Clinical Trial Summary

The purpose of this research study is to see if and how mindfulness meditation affects pain. Specifically, we are interested in assessing if mindfulness is associated with the release of naturally occurring opiates in the body, in response to intravenous (IV) administration of the opioid antagonist naloxone during a chronic low back pain provoking procedure.

Clinical Trial Description

The purpose of this psychophysical and pharmacologic study is to determine if meditation induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone during a pain evoking straight leg raise test in response to double-blind intravenous administration (IV) of naloxone/placebo-saline. The aim of this study is to determine if mindfulness-based analgesia is associated with the release of endogenous opioids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04034004
Study type Interventional
Source University of California, San Diego
Contact
Status Completed
Phase Early Phase 1
Start date January 1, 2021
Completion date December 22, 2022
View Details
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