Clinical Trials Logo
  1. Home
  2. Pain
  3. NCT03817034
  4. Details
NCT03817034 Clinical Trial

Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption

Pain Clinical Trial

Official title:
Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT03817034
Other study ID # 2018P002053
Secondary ID
Status Withdrawn
Phase Early Phase 1
First received
Last updated
Start date March 11, 2021
Est. completion date March 11, 2021

Study information
Verified date March 2021
Source Massachusetts General Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators are performing this research study to investigate the efficacy of local infiltration of the surgical wound combining dexmedetomidine, ropivacaine, and ketorolac (treatment group) versus the current standard of care (historical control group), for post-operative pain management.

Description:

During this research study, patients recommended for a rectus sheath block during surgery will receive a novel combination of non-opioid drugs. Data from the treatment group will be compared to surgical outcomes of a historically matched control group to investigate the ability of this drug combination to reduce post-operative pain and post-operative opioid consumption.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date March 11, 2021
Est. primary completion date March 11, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 99 Years
Eligibility Inclusion Criteria: - Age greater than 18 years - American Society of Anesthesiologist Physical Status Classification 1-3 - Undergoing surgery requiring a rectus sheath block Exclusion Criteria: - American Society of Anesthesiologist Physical Status Classification of 4 or beyond - history of opiate of illicit substance abuse, chronic pain, or neurological dysfunction

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Multimodal analgesia
Subjects will be given a rectus sheath block containing dexmedetomidine, ropivacaine, and ketorolac

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Massachusetts General Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary Change in post-operative opioid consumption Decreased post-operative opioid consumption associated with use of multimodal analgesia 48 hours
Primary Change in post-operative pain scores Decreased post-operative pain scores associated with use of multimodal analgesia 48 hours
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05559255 - Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI N/A
Completed NCT04748367 - Leveraging on Immersive Virtual Reality to Reduce Pain and Anxiety in Children During Immunization in Primary Care N/A
Terminated NCT04356352 - Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain Phase 2/Phase 3
Completed NCT05057988 - Virtual Empowered Relief for Chronic Pain N/A
Completed NCT04466111 - Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain
Recruiting NCT06206252 - Can Medical Cannabis Affect Opioid Use?
Completed NCT05868122 - A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy Phase 3
Active, not recruiting NCT05006976 - A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study N/A
Completed NCT03273114 - Cognitive Functional Therapy (CFT) Compared With Core Training Exercise and Manual Therapy (CORE-MT) in Patients With Chronic Low Back Pain N/A
Enrolling by invitation NCT06087432 - Is PNF Application Effective on Temporomandibular Dysfunction N/A
Completed NCT05508594 - Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001 Phase 2/Phase 3
Recruiting NCT03646955 - Partial Breast Versus no Irradiation for Women With Early Breast Cancer N/A
Active, not recruiting NCT03472300 - Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Completed NCT03678168 - A Comparison Between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries N/A
Completed NCT03286543 - Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System N/A
Completed NCT03931772 - Online Automated Self-Hypnosis Program N/A
Completed NCT02913027 - Can We Improve the Comfort of Pelvic Exams? N/A
Terminated NCT02181387 - Acetaminophen Use in Labor - Does Use of Acetaminophen Reduce Neuraxial Analgesic Drug Requirement During Labor? Phase 4
Recruiting NCT06032559 - Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment Phase 3
Active, not recruiting NCT03613155 - Assessment of Anxiety in Patients Treated by SMUR Toulouse and Receiving MEOPA as Part of Their Care