Pain Clinical Trial
Official title:
Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia? - A Study of Healthy Volunteers
The purpose of this prospective study is to investigate the degree of association between the volume of important pain-relevant structures in the brain and the size of the areas of secondary hyperalgesia.
The healthy study participants will be included from the cohort of a previous study
(NCT02527395) where areas of secondary hyperalgesia, heat pain detection thresholds, pain
during 1 min. thermal stimulation and test results from the Pain Catastrophizing Scale and
the Hospital Anxiety and Depression Score will be retrieved. The study consists of 1 study
day. The study day will be conducted at a maximum of 2 months and a minimum of 2 weeks after
the completion of the previous study (NCT02527395).The results of the previous study
(NCT02527395) will be blinded until all participants have completed the study day.
All study participants will complete a MRI-scan of the brain.
The MRI scans will be performed with a Siemens MAGNETOM Verio 3 tesla, with b17 software,
and a 32-channel head coil. The MRI-scan sequence is as follows:
- 3D Localiser
- 3D T1 weighted iso
- AX Diffusion tensor imaging
- AX Epi resting state fMRI
- AX Gre field map
- AX Epi ASL
- AX T2-weighted blade
- AX T2-weighted flair
- AX T2-weighted* Gre
Total MRI-scan time is estimated to approximately 40 minutes.
;
Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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