Pain Clinical Trial
Official title:
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery
Opioid tolerance in the perioperative period is inevitable especially with ultra-short acting agents such as remifentanil. Existing evidence had shown that opioid induced hyperalgesia due to neuroplastic changes in the central as well as peripheral nervous system leads to sensitization of pro-nociceptive pathways. However there has been a controversy of occurrence of such tolerance following the use of remifentanil and the quality of recovery as compared to conventional opioids. The investigators evaluated the occurrence of opioid tolerance and other significant adverse effects with remifentanil in subjects undergoing head and neck surgeries. The investigators studied ASA physical status I and II adult subjects undergoing elective head and neck procedures, under general anesthesia with minimum expected duration of 2 hours. The remifentanil infusion was used in one group and intermittent boluses of morphine or fentanyl administered in another group. They were evaluated for immediate post-operative pain by using numerical rating scale (NRS), the opioid consumption, post-operative nausea, vomiting, other significant adverse effects of remifentanil and the time to discharge from PACU.
We have studied 222 of you between the age of 21 and 80 years, over a period of 2 years at
Singapore General Hospital, Singapore. All of you were ASA I to II and scheduled for
elective head and neck surgery with minimum expected duration of 2 hours, requiring general
anesthesia. The methodology of this observational study was approved by the International
review Board at Singapore General Hospital, Singapore. Informed consent was obtained from
you prior to the procedure. If you had previous history of either drug or alcohol abuse,
have been using opioids for long term, mental disorder with difficult to understand pain
scoring system, ASA physical status of III and above, your surgical procedure warranting
elective postoperative ventilation you would have been excluded from this study. The study
was not randomized and the choice of intra-operative opioids were left to the discretion of
anesthesiologist attending you.
You were not premedicated and instructed about 11 point numerical rating score after
reaching induction room. Upon arrival in the operating room, you were monitored with EKG,
non-invasive arterial pressure and pulse oxymetry. The attending anesthesiologist gave you
either Remifentanil or conventional opioids at standard doses from the induction of
anesthesia to end of surgery. Sevoflurane, desflurane or isoflurane with oxygen air mixture
were utilized to maintain anesthesia at the minimum alveolar concentration of 0.8 to 1.2 .
Choice of opioid, volatile agent, muscle relaxants, airway was left to the discretion of the
anesthesiologist attending the patient. Parameters including type of volatile anesthetic
agent, method of air way establishment, the duration of surgery, the remifentanil used
(microgram.kg-1 ) and amount of morphine or fentanyl (microgram.kg-1) were documented. Upon
arrival to the PACU you were assessed for the pain.
For the first 15 minutes behavioral score (0 - calm patient with no verbal or behavioral
manifestation of pain, 1 - behavioral or verbal expression of pain, and 2 - intense
behavioral or verbal manifestation [crying or extreme agitation]) were utilized and
subsequently numerical rating scale (NRS) was used for every 5 minutes until discharge from
the PACU.
Intravenous morphine or fentanyl was used to treat immediate post-operative pain in PACU
till the NRS is less than or equal to 3 as per PACU acute pain management protocol. Maximum
NRS of pain, amount of morphine or fentanyl used for rescue analgesia, occurrence of either
nausea or vomiting and the antiemetic used was gathered every 15 minutes. Upon discharge
from the PACU, total opioids consumed, duration of the PACU (defined by time since admission
to decision made for discharge by PACU anesthesiologists, to rule out the prolong PACU stay
from other reasons) and occurrence of other potential side effects that affect the quality
of recovery such as drowsy, nausea, vomiting, shivering and evidence of respiratory
suppression ( desaturation or bradypnea ) were documented.
Our primary outcome was amount of opioids used in PACU and the secondary outcomes were the
duration of PACU stay and the adverse effects of remifentanil that influence the recovery as
stated above.
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Observational Model: Case Control, Time Perspective: Prospective
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