Pain Clinical Trial
Official title:
Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on the Patients That is Undergoing Abdominal Hysterectomy
The aim of this study is to investigate comparison of preemptive analgesic effects of dexketoprofen versus dexmedetomidine on the patients that is undergoing abdominal hysterectomy.
Abdominal hysterectomy is associated with moderate to severe postoperative pain which has
unfavorable effects on patient's recovery and procedure's outcome. Administration of opioid
analgesics is routinely practiced but is limited with dose-related adverse effects.[1]
Within this concept, combining an opioid with different analgesics acting by different
mechanisms as multimodal analgesia is recommended for effective post-operative pain control
Dexketoprofen trometamol is a newly developed, centrally acting NSAID with potency similar
to that of μ-opioid agonists.[4] In a number of studies in different pain models, it has
been proven to have a good analgesic efficacy and tolerability.
Dexmedetomidine is a highly selective α2 adrenoceptor agonist that provides sedation,
analgesia, and sympatholysis. These characteristics make dexmedetomidine useful anesthetic
adjunct during operation. Previous studies report that intravenous has a definitive role in
postoperative analgesia through the reduction of opioid consumption The aim of this
prospective randomized, double-blind study is to evaluate the analgesic efficacy and opioid
sparing effects of preemptive single dose of dexketoprofen trometamol in comparison with
dexmedetomidine in the patients abdominal hysterectomy , over a 24-hour (h) investigation
period.
After institutional approval and informed consent had been obtained, 60 patients scheduled
for abdominal hysterectomy randomly allocated into two equal groups. Patients received ıv
dexketoprofen 50 mg (Group I), ıv dexmedetomidine 1mcg/kg (Group II) after anesthesia
induction and 10 minutes (min) before surgical incision. Patient controlled analgesia was
supplied postoperatively using morphine. Hemodynamics, visual analogue scale (VAS), sedation
score, morphine consumption, and side effects were recorded every and at 2, 6, 12 and 24 h
after surgery.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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