Pain Clinical Trial
Official title:
A Pilot Randomized, Placebo-Controlled Study to Test Auranofin (Ridaura®) to Control the Paclitaxel-Induced Pain Syndrome (PIAPS)
This randomized pilot clinical trial studies whether auranofin will relieve pain following paclitaxel in patients who have previously experienced paclitaxel-induced pain. Auranofin is a drug given by mouth to treat other diseases such as rheumatoid arthritis, and is being studied to see if it will decrease pain following paclitaxel.
PRIMARY OBJECTIVES:
I. Determine whether one dose of auranofin given the day following administration of
paclitaxel decreases pain as assessed by daily completion of the Modified Brief Pain
Inventory scale for seven days.
SECONDARY OBJECTIVES:
I. Assess whether auranofin is well tolerated in this setting.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive auranofin orally (PO) on day 2.
ARM II: Patients receive placebo PO on day 2.
After completion of study treatment, patients are followed up at 21-28 days.
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